DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF432

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001309213.1	Gene:	ZNF432 / 9668	HGNCID:	20810	Length:	652	Species:	Homo sapiens

Alignment Length:	507	Identity:	144/507 - (28%)
Similarity:	223/507 - (43%)	Gaps:	84/507 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 VIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDE 147
            :|::.|||.|. |.....::.|.|...|.|...:..           ||:|:.:    |:.::..
Human     1 MINAQELLTLE-DVTVEFTWEEWQLLGPFQKDLYRD-----------VMLEIYS----NLLSMGY 49

  Fly   148 ELAEED--------RRIFAMTVDEEEEFLTEEVDQDDELSE--EEHQLAQSGDQQEEH------- 195
            ::::.|        ...:.|..:.......|..:.||.|.:  |..::.:|.:|..||
Human    50 QVSKPDALSKLERGEEPWTMEDERHSRICPENNEVDDHLQDHLENQRMLKSVEQYHEHNAFGNTA 114

  Fly   196 -------ITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMND---SGAHDAIL--DCQMIVI 248
                   :..|:...|   |:...|:|:.. ::|.:....|:.|.   ||...:.|  :.:.:..
Human   115 SQTKSLCLFRENHDTF---ELYIKTLKSNL-SLVNQNKSCEINNSTKFSGDGKSFLHGNYEELYS 175

  Fly   249 PAEGAIDEVIGEETLELEGDGREEHLLPEAEDVCED--EDFLEES--LDSAPPTAGEALPYVCTV 309
            .|:.::.........::....|...:  |...||.:  :.|:::|  .|......||. ||.||:
Human   176 AAKFSVSTKANSTKSQVSKHQRTHEI--EKNHVCSECGKAFVKKSQLTDHERVHTGEK-PYGCTL 237

  Fly   310 CQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKP-------------- 360
            |.|.|.::.|||:|.|.|..||.:.|.||||.........||..|||..||
Human   238 CAKVFSRKSRLNEHQRIHKREKSFICSECGKVFTMKSRLIEHQRTHTGEKPYICNECGKGFPGKR 302

  Fly   361 ----HQ----------CSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTH 411
                ||          ||.||:.:...|.|.:|:|||..:|||.|.:||:|:....::..|:..|
Human   303 NLIVHQRNHTGEKSYICSECGKGFTGKSMLIIHQRTHTGEKPYICSECGKGFTTKHYVIIHQRNH 367

  Fly   412 TGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCD 476
            |||:||.|:.|.|.:...|.:.:|:.:|||:|.:.|..||.|..:||....|...|:..|::.|.
Human   368 TGEKPYICNECGKGFTMKSRMIEHQRTHTGEKPYICSECGKGFPRKSNLIVHQRNHTVEKSYLCS 432

  Fly   477 VCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            .||..||..|.|..|.|.|:||||:.|..|.|.||.|.||..|.|.|..|.|
Human   433 ECGKGFTVKSMLIIHQRTHTGEKPYTCSECGKGFPLKSRLIVHQRTHTGEKP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	3/7 (43%)
		COG5048	<297..451	CDD:227381	65/181 (36%)
		C2H2 Zn finger	307..327	CDD:275368	10/19 (53%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	56/135 (41%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	10/19 (53%)
ZNF432	NP_001309213.1	KRAB	8..68	CDD:214630	12/75 (16%)
		KRAB	8..47	CDD:279668	11/54 (20%)
		COG5048	<87..380	CDD:227381	82/299 (27%)
		C2H2 Zn finger	207..227	CDD:275368	4/19 (21%)
		C2H2 Zn finger	235..255	CDD:275368	10/19 (53%)
		COG5048	259..636	CDD:227381	84/226 (37%)
		C2H2 Zn finger	263..283	CDD:275368	7/19 (37%)
		C2H2 Zn finger	291..311	CDD:275368	2/19 (11%)
		C2H2 Zn finger	319..339	CDD:275368	8/19 (42%)
		zf-H2C2_2	331..356	CDD:290200	12/24 (50%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		C2H2 Zn finger	375..395	CDD:275368	5/19 (26%)
		C2H2 Zn finger	403..423	CDD:275368	7/19 (37%)
		C2H2 Zn finger	431..451	CDD:275368	9/19 (47%)
		zf-H2C2_2	443..466	CDD:290200	11/22 (50%)
		C2H2 Zn finger	459..479	CDD:275368	10/19 (53%)
		zf-H2C2_2	472..494	CDD:290200	6/13 (46%)
		C2H2 Zn finger	487..507	CDD:275368
		zf-H2C2_2	500..523	CDD:290200
		C2H2 Zn finger	515..535	CDD:275368
		zf-H2C2_2	527..551	CDD:290200
		C2H2 Zn finger	543..563	CDD:275368
		C2H2 Zn finger	571..591	CDD:275368
		C2H2 Zn finger	599..619	CDD:275368
		zf-H2C2_2	612..636	CDD:290200
		C2H2 Zn finger	627..647	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910