DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and ZBTB47

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_660149.2	Gene:	ZBTB47 / 92999	HGNCID:	26955	Length:	747	Species:	Homo sapiens

Alignment Length:	562	Identity:	137/562 - (24%)
Similarity:	227/562 - (40%)	Gaps:	95/562 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CKLHKPLQEEIDLGSEGSTTLASM-------------LNYCTGLSFEPQDGAAMPQHICLHCLQL 72
            |||....:.|.:||..|:.:....             |:..||...:|..|
Human   208 CKLEGGEELEEELGGSGTYSRREQSQIIVEVNLNNQTLHVSTGPEGKPGAG-------------- 258

  Fly    73 LEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNE 137
                        .|...:.||.::.......|.:.....:.::.::::......||       .|
Human   259 ------------PSPATVVLGREDGLQRHSDEEEEDDEEEEEEEEEEEGGGSGREE-------EE 304

  Fly   138 EQENVANLDEELAEEDRRIFAMTVDEEEEFLTEE--VDQDDELSEEEH-QLAQSGDQQEEHITME 199
            |:|..:..:||..|||..   ...:||||...||  .:||.|.||||. :..::|.:|....:..
Human   305 EEEGGSQGEEEEEEEDGH---SEQEEEEEEEEEEGPSEQDQESSEEEEGEEGEAGGKQGPRGSRS 366

  Fly   200 SVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEG----------AI 254
            |..:..|........:.......|.|.| |.....|....         |..|          |.
Human   367 SRADPPPHSHMATRSRENARRRGTPEPE-EAGRRGGKRPK---------PPPGVASASARGPPAT 421

  Fly   255 DEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCR 319
            |.:..:..||    .::.|...:...|..:..:||:.::     ...:...:|..|.|.|..:..
Human   422 DGLGAKVKLE----EKQHHPCQKCPRVFNNRWYLEKHMN-----VTHSRMQICDQCGKRFLLESE 477

  Fly   320 LNQHMRSHVDEKQYECEECGKRLKHLRNYKEH-MLTHTNV-KPHQCSICGRFYRTTSSLAVHKRT 382
            |..|.::.. |:..:|..|||..|.|.:..|| .:.|... |...|.||.:.:.|.:.:..|...
Human   478 LLLHRQTDC-ERNIQCVTCGKAFKKLWSLHEHNKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVA 541

  Fly   383 HAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTC 447
            |.:..|:.|:.||:.:.....|:.|.|.|:||:|:.|:.|::.:.....||.|...|.|.|.|.|
Human   542 HTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCNERFQYKYQLRSHMSIHIGHKQFMC 606

  Fly   448 EICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPT 512
            :.||...:.|..:.:||..|:|.|.:.|::||.:||...|:..|.|.|:||||:.|:||.:.|
Human   607 QWCGKDFNMKQYFDEHMKTHTGEKPYICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRF-- 669

  Fly   513 KKRLASHMRVHNKES-PVTATVAVQSIN-----PPSR-QAGA 547
              |.::.::.|.::. .|:.|:|...:.     ||:: ||.|
Human   670 --RFSNMLKAHKEKCFRVSHTLAGDGVPAAPGLPPTQPQAHA 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	13/82 (16%)
		COG5048	<297..451	CDD:227381	44/155 (28%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	8/20 (40%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		COG5048	<387..523	CDD:227381	47/135 (35%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
ZBTB47	NP_660149.2	BTB	4..110	CDD:279045
		BTB	18..113	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..424		45/226 (20%)
		C2H2 Zn finger	438..459	CDD:275368	3/25 (12%)
		C2H2 Zn finger	465..484	CDD:275368	6/18 (33%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
		COG5048	520..>601	CDD:227381	23/80 (29%)
		C2H2 Zn finger	522..542	CDD:275368	5/19 (26%)
		zf-H2C2_2	534..559	CDD:290200	6/24 (25%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		zf-H2C2_2	562..585	CDD:290200	9/22 (41%)
		cxxc_20_cxxc	577..>621	CDD:274982	13/43 (30%)
		C2H2 Zn finger	578..598	CDD:275368	5/19 (26%)
		C2H2 Zn finger	606..626	CDD:275368	6/19 (32%)
		zf-H2C2_2	618..643	CDD:290200	9/24 (38%)
		COG5048	630..>701	CDD:227381	23/74 (31%)
		C2H2 Zn finger	634..654	CDD:275368	8/19 (42%)
		zf-H2C2_2	646..669	CDD:290200	11/22 (50%)
		C2H2 Zn finger	662..678	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..747		5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149937
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930