DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF845

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001308451.1	Gene:	ZNF845 / 91664	HGNCID:	25112	Length:	970	Species:	Homo sapiens

Alignment Length:	225	Identity:	93/225 - (41%)
Similarity:	126/225 - (56%)	Gaps:	0/225 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGR 368
            ||.|..|.|.|.|:..|..|.|.|..||.|:|.||||..........|...||..|.::|:.||:
Human   270 PYKCNDCGKTFSQELTLTCHHRLHTGEKHYKCSECGKTFSRNSALVIHKAIHTGEKSYKCNECGK 334

  Fly   369 FYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLR 433
            .:..||.|..|:|.|..:|||.|::|.:.::...:|.||:..||||:||.|:.|.:.:...|||.
Human   335 TFSQTSYLVYHRRLHTGEKPYKCEECDKAFSFKSNLERHRKIHTGEKPYKCNECSRTFSRKSSLT 399

  Fly   434 QHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGE 498
            :|:..|||:|.:.|..||...||.|....|..:|:|.|.:||:.|..||:|.|||..|.|:|:||
Human   400 RHRRLHTGEKPYKCNDCGKTFSQMSSLVYHRRLHTGEKPYKCEECDEAFSFKSNLERHRRIHTGE 464

  Fly   499 KPFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            ||:||..|.|.|.....|..|.|:|..|.|
Human   465 KPYKCNDCGKTFSQTSSLVYHRRLHTGEKP 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	57/146 (39%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	58/135 (43%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		zf-H2C2_2	487..510	CDD:290200	13/22 (59%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
ZNF845	NP_001308451.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	169..564	CDD:227381	93/225 (41%)
		C2H2 Zn finger	217..237	CDD:275368
		C2H2 Zn finger	245..265	CDD:275368
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		COG5048	381..813	CDD:227381	49/114 (43%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	10/24 (42%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		C2H2 Zn finger	441..461	CDD:275368	10/19 (53%)
		zf-H2C2_2	453..478	CDD:290200	14/24 (58%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..517	CDD:275368
		zf-H2C2_2	509..534	CDD:290200
		C2H2 Zn finger	525..545	CDD:275368
		zf-H2C2_2	537..560	CDD:290200
		C2H2 Zn finger	553..573	CDD:275368
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		zf-H2C2_2	649..674	CDD:290200
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368
		C2H2 Zn finger	721..741	CDD:275368
		C2H2 Zn finger	749..769	CDD:275368
		zf-H2C2_2	761..786	CDD:290200
		C2H2 Zn finger	777..797	CDD:275368
		C2H2 Zn finger	805..825	CDD:275368
		C2H2 Zn finger	833..853	CDD:275368
		zf-H2C2_2	845..870	CDD:290200
		C2H2 Zn finger	861..881	CDD:275368
		zf-H2C2_2	873..898	CDD:290200
		C2H2 Zn finger	889..909	CDD:275368
		C2H2 Zn finger	917..937	CDD:275368
		C2H2 Zn finger	945..965	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910