DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF700

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001258777.1	Gene:	ZNF700 / 90592	HGNCID:	25292	Length:	745	Species:	Homo sapiens

Alignment Length:	231	Identity:	96/231 - (41%)
Similarity:	136/231 - (58%)	Gaps:	6/231 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNV------KPHQ 362
            ||.|..|.||||....|..|.|:|..||.|||:||||..:::::.:.|..|..::      :|::
Human   448 PYECKECGKAFRSTSHLRVHGRTHTGEKPYECKECGKAFRYVKHLQIHERTEKHIRMPSGERPYK 512

  Fly   363 CSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYY 427
            ||||.:.:.:..|...|::||..:|||.|:|||:.:...:.||.|:.|||||:||.|..|.||:.
Human   513 CSICEKGFYSAKSFQTHEKTHTGEKPYECNQCGKAFRCCNSLRYHERTHTGEKPYECKQCGKAFR 577

  Fly   428 DSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHV 492
            .:|.||.|:.:|||:|.:.|:.||...|..|..:||...|:|.|.::|..||.||...|||..|.
Human   578 SASHLRMHERTHTGEKPYECKQCGKAFSCASNLRKHGRTHTGEKPYECKQCGKAFRSASNLQMHE 642

  Fly   493 RLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            |.|:||||::|:.|.|||........|.|.|..|.|
Human   643 RTHTGEKPYECKECEKAFCKFSSFQIHERKHRGEKP 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	62/152 (41%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	61/135 (45%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	13/22 (59%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
ZNF700	NP_001258777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		KRAB	27..>69	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	169..191	CDD:275368
		C2H2 Zn finger	199..219	CDD:275368
		COG5048	224..636	CDD:227381	76/187 (41%)
		C2H2 Zn finger	227..247	CDD:275368
		zf-H2C2_2	243..264	CDD:290200
		C2H2 Zn finger	255..275	CDD:275368
		zf-H2C2_2	268..292	CDD:290200
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	298..320	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	379..403	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		zf-H2C2_2	407..432	CDD:290200
		C2H2 Zn finger	423..443	CDD:275368
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		zf-H2C2_2	463..488	CDD:290200	13/24 (54%)
		C2H2 Zn finger	479..498	CDD:275368	6/18 (33%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	525..550	CDD:290200	11/24 (46%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	553..578	CDD:290200	14/24 (58%)
		C2H2 Zn finger	569..589	CDD:275368	8/19 (42%)
		zf-H2C2_2	581..606	CDD:290200	10/24 (42%)
		C2H2 Zn finger	597..617	CDD:275368	7/19 (37%)
		zf-H2C2_2	609..634	CDD:290200	10/24 (42%)
		C2H2 Zn finger	625..645	CDD:275368	10/19 (53%)
		zf-H2C2_2	637..660	CDD:290200	12/22 (55%)
		C2H2 Zn finger	653..673	CDD:275368	7/19 (37%)
		C2H2 Zn finger	681..701	CDD:275368
		C2H2 Zn finger	709..729	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910