DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF160

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	228	Identity:	92/228 - (40%)
Similarity:	134/228 - (58%)	Gaps:	1/228 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 AGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQC 363
            :||. ||.|..|.|.|.|..:|.:|.|.|..||.|:|.:||:......:...|...||..||::|
Human   560 SGEK-PYKCNECGKVFAQTSQLARHWRVHTGEKPYKCNDCGRAFSDRSSLTFHQAIHTGEKPYKC 623

  Fly   364 SICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYD 428
            ..||:.:|..|.||.|:|.|..:|||.|::||:.::...:|..||:.||||:||.|:.|.|.:..
Human   624 HECGKVFRHNSYLATHRRIHTGEKPYKCNECGKAFSMHSNLTTHKVIHTGEKPYKCNQCGKVFTQ 688

  Fly   429 SSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVR 493
            :|.|..|:.:|||:|.:.|..||...|.:|....|..:|:|.|.:||:.||..||..::|..|.|
Human   689 NSHLANHQRTHTGEKPYRCNECGKAFSVRSSLTTHQAIHTGKKPYKCNECGKVFTQNAHLANHRR 753

  Fly   494 LHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKE 526
            :|:||||::|..|.|||..:..|.:||.:|..|
Human   754 IHTGEKPYRCTECGKAFRVRSSLTTHMAIHTGE 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	60/151 (40%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	4/19 (21%)
		C2H2 Zn finger	363..383	CDD:275368	9/19 (47%)
		COG5048	<387..523	CDD:227381	56/135 (41%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523
		C2H2 Zn finger	259..279	CDD:275368
		zf-H2C2_2	271..295	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..350	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		zf-H2C2_2	355..380	CDD:290200
		COG5048	367..810	CDD:227381	92/228 (40%)
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
		zf-H2C2_2	411..436	CDD:290200
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	483..503	CDD:275368
		zf-H2C2_2	496..519	CDD:290200
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	523..548	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
		zf-H2C2_2	551..576	CDD:290200	8/16 (50%)
		C2H2 Zn finger	567..587	CDD:275368	8/19 (42%)
		C2H2 Zn finger	595..615	CDD:275368	4/19 (21%)
		zf-H2C2_2	607..632	CDD:290200	8/24 (33%)
		C2H2 Zn finger	623..643	CDD:275368	9/19 (47%)
		zf-H2C2_2	635..659	CDD:290200	11/23 (48%)
		C2H2 Zn finger	651..671	CDD:275368	6/19 (32%)
		zf-H2C2_2	663..688	CDD:290200	12/24 (50%)
		C2H2 Zn finger	679..699	CDD:275368	6/19 (32%)
		zf-H2C2_2	691..715	CDD:290200	9/23 (39%)
		C2H2 Zn finger	707..727	CDD:275368	6/19 (32%)
		zf-H2C2_2	719..744	CDD:290200	9/24 (38%)
		C2H2 Zn finger	735..755	CDD:275368	8/19 (42%)
		zf-H2C2_2	747..770	CDD:290200	11/22 (50%)
		C2H2 Zn finger	763..783	CDD:275368	8/19 (42%)
		zf-H2C2_2	775..800	CDD:290200	5/12 (42%)
		C2H2 Zn finger	791..811	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910