DRSC/TRiP Functional Genomics Resources

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Protein Alignment dwg and ZNF394

DIOPT Version :9

Sequence 1:NP_477338.3 Gene:dwg / 31265 FlyBaseID:FBgn0000520 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_115540.2 Gene:ZNF394 / 84124 HGNCID:18832 Length:561 Species:Homo sapiens


Alignment Length:524 Identity:139/524 - (26%)
Similarity:216/524 - (41%) Gaps:98/524 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 SFEPQDGAAM--PQHICLHCLQLL-------EQAFN---------FKRMVIDSDELLRLGLDEAR 98
            |:||...||.  |:...||..||.       |:|.:         .:..::..:::|.|.:.|..
Human    48 SWEPNYPAASPDPETSRLHFRQLRYQEVAGPEEALSRLRELCRRWLRPELLSKEQILELLVLEQF 112

  Fly    99 CSSFHES-----QTHSPNQSQQH----DQQQQAFDSTE-------EYVMIEMLNEEQENV--ANL 145
            .:...|.     :.|.|...::.    ...|:|.|.|.       |...:.:..||.|.:  |..
Human   113 LTILPEELQAWVREHCPESGEEAVAVVRALQRALDGTSSQGMVTFEDTAVSLTWEEWERLDPARR 177

  Fly   146 D--EELAEEDRRIFAMTVD-------EEEEF-----LTEEVDQDDELSE----EEHQLAQSGDQQ 192
            |  .|.|::|.   ..||.       |.:|.     :.||.:...:|.|    :....::.|...
Human   178 DFCRESAQKDS---GSTVPPSLESRVENKELIPMQQILEEAEPQGQLQEAFQGKRPLFSKCGSTH 239

  Fly   193 EEHITMES-------VHEFQPAE-VEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIP 249
            |:.:..:|       :.....|| :..::..|:..:|..|:.:...:.:|.....::.||.|. .
Human   240 EDRVEKQSGDPLPLKLENSPEAEGLNSISDVNKNGSIEGEDSKNNELQNSARCSNLVLCQHIP-K 303

  Fly   250 AEGAIDEVIGEETLELEGDGREEH---------------LLPEAEDVCEDEDFLEESLDSAPPTA 299
            ||...|.              |||               |.|...|  ..:.|...||.......
Human   304 AERPTDS--------------EEHGNKCKQSFHMVTWHVLKPHKSD--SGDSFHHSSLFETQRQL 352

  Fly   300 GEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCS 364
            .|..||.|..|.|:|:|:..|.:|.|.|..||.|.|:||||.........:|..|||..||:.|.
Human   353 HEERPYKCGNCGKSFKQRSDLFRHQRIHTGEKPYGCQECGKSFSQSAALTKHQRTHTGEKPYTCL 417

  Fly   365 ICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDS 429
            .||..:|..|.|..|:.||:..|.:.|::||. .....:|.||:..|.|||||.|:.|:|::...
Human   418 KCGERFRQNSHLNRHQSTHSRDKHFKCEECGE-TCHISNLFRHQRLHKGERPYKCEECEKSFKQR 481

  Fly   430 SSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRL 494
            |.|.:|...|||:|.:.|.:||...:|.:...||..:|:|.|.:||..||..|..:::|..|.|:
Human   482 SDLFKHHRIHTGEKPYGCSVCGKRFNQSATLIKHQRIHTGEKPYKCLECGERFRQSTHLIRHQRI 546

  Fly   495 HSGE 498
            |..:
Human   547 HQNK 550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dwgNP_477338.3 zf-AD 14..91 CDD:214871 12/56 (21%)
COG5048 <297..451 CDD:227381 59/153 (39%)
C2H2 Zn finger 307..327 CDD:275368 8/19 (42%)
C2H2 Zn finger 335..355 CDD:275368 6/19 (32%)
C2H2 Zn finger 363..383 CDD:275368 7/19 (37%)
COG5048 <387..523 CDD:227381 41/112 (37%)
C2H2 Zn finger 391..411 CDD:275368 6/19 (32%)
zf-H2C2_2 403..426 CDD:290200 12/22 (55%)
C2H2 Zn finger 419..439 CDD:275368 6/19 (32%)
C2H2 Zn finger 447..467 CDD:275368 6/19 (32%)
C2H2 Zn finger 475..495 CDD:275368 7/19 (37%)
zf-H2C2_2 487..510 CDD:290200 4/12 (33%)
C2H2 Zn finger 503..523 CDD:275368
ZNF394NP_115540.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..61 5/12 (42%)
SCAN 60..170 CDD:128708 20/109 (18%)
KRAB_A-box 155..214 CDD:322003 13/61 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..201 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..285 8/53 (15%)
C2H2 Zn finger 337..353 CDD:275368 3/15 (20%)
COG5048 356..>420 CDD:227381 26/63 (41%)
C2H2 Zn finger 360..380 CDD:275368 8/19 (42%)
C2H2 Zn finger 388..408 CDD:275368 6/19 (32%)
zf-C2H2 414..436 CDD:306579 7/21 (33%)
C2H2 Zn finger 416..436 CDD:275368 7/19 (37%)
C2H2 Zn finger 444..463 CDD:275368 6/19 (32%)
SFP1 <464..543 CDD:227516 30/78 (38%)
C2H2 Zn finger 471..491 CDD:275368 6/19 (32%)
C2H2 Zn finger 499..519 CDD:275368 6/19 (32%)
C2H2 Zn finger 527..547 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
21.870

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