DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF239

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_011538534.1	Gene:	ZNF239 / 8187	HGNCID:	13031	Length:	602	Species:	Homo sapiens

Alignment Length:	522	Identity:	144/522 - (27%)
Similarity:	227/522 - (43%)	Gaps:	105/522 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 CLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSP-NQSQQHDQQQQAFDSTEEYVMI 132
            |.|..|.:....|   :.|.::.|   ::.|....||:|:.| ..|.|.|.|    ||:.::..
Human   174 CQQWGEASSPISR---NRDSVMTL---QSGCFENIESETYLPLKVSSQIDTQ----DSSVKFCK- 227

  Fly   133 EMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHIT 197
               ||.|::         :|.||:|.|....|.:.:                   .|:...|::.
Human   228 ---NEPQDH---------QESRRLFVMEESTERKVI-------------------KGESCSENLQ 261

  Fly   198 MESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEET 262
            ::.|.:.|  |:....:..|   ...:..:.:...|.      :||.         ..::.|.::
Human   262 VKLVSDGQ--ELASPLLNGE---ATCQNGQLKESLDP------IDCN---------CKDIHGWKS 306

  Fly   263 LELEGDGREEHLLPEAEDVCEDED---FLEESLDSAP----PTAGEALPYVCTVCQKAFRQQCRL 320
            ..:....:..|   ..|..|:..:   .|..|.|..|    .||.:  .|.|:.|.|.|.|...|
Human   307 QVVSCSQQRAH---TEEKPCDHNNCGKILNTSPDGHPYEKIHTAEK--QYECSQCGKNFSQSSEL 366

  Fly   321 NQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAE 385
            ..|.|.|.:||.|:||:|||......:...|...||:.||::|..||:.:..:|||.:|...|..
Human   367 LLHQRDHTEEKPYKCEQCGKGFTRSSSLLIHQAVHTDEKPYKCDKCGKGFTRSSSLLIHHAVHTG 431

  Fly   386 KKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEIC 450
            :|||.||:||:|::....|..|:..||||:||.|:.|..::...|:|..|:..|||::.:.|..|
Human   432 EKPYKCDKCGKGFSQSSKLHIHQRVHTGEKPYECEECGMSFSQRSNLHIHQRVHTGERPYKCGEC 496

  Fly   451 GVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKR 515
            |.|.||.|....|..:|:|.|.::|..||..|:.:|:|..|:|:|:||||:.|..|.|.|....:
Human   497 GKGFSQSSNLHIHRCIHTGEKPYQCYECGKGFSQSSDLRIHLRVHTGEKPYHCGKCGKGFSQSSK 561

  Fly   516 LASHMRVHNKESPVTATVAVQSINPPSRQAGAEGATGGGATGGSPTGGGATGGSATNLHITE-VH 579
            |..|.|||..|.|...                           |..|.|.:  .::||||.: ||
Human   562 LLIHQRVHTGEKPYEC---------------------------SKCGKGFS--QSSNLHIHQRVH 597

  Fly   580 EQ 581
            ::
Human   598 KK 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	5/21 (24%)
		COG5048	<297..451	CDD:227381	58/153 (38%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	55/135 (41%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
ZNF239	XP_011538534.1	C2H2 Zn finger	326..345	CDD:275368	4/18 (22%)
		COG5048	<337..537	CDD:227381	76/201 (38%)
		C2H2 Zn finger	353..373	CDD:275368	8/19 (42%)
		zf-H2C2_2	365..390	CDD:290200	12/24 (50%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	393..418	CDD:290200	8/24 (33%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		zf-H2C2_2	421..446	CDD:290200	12/24 (50%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		zf-H2C2_2	453..474	CDD:290200	9/20 (45%)
		C2H2 Zn finger	465..485	CDD:275368	5/19 (26%)
		zf-H2C2_2	481..502	CDD:290200	8/20 (40%)
		C2H2 Zn finger	493..513	CDD:275368	8/19 (42%)
		zf-C2H2	519..541	CDD:278523	8/21 (38%)
		C2H2 Zn finger	521..541	CDD:275368	8/19 (42%)
		zf-H2C2_2	533..558	CDD:290200	12/24 (50%)
		COG5048	545..>602	CDD:227381	22/84 (26%)
		C2H2 Zn finger	549..569	CDD:275368	7/19 (37%)
		zf-H2C2_2	562..586	CDD:290200	10/52 (19%)
		C2H2 Zn finger	577..597	CDD:275368	7/48 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910