DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF34

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_085057.3	Gene:	ZNF34 / 80778	HGNCID:	13098	Length:	560	Species:	Homo sapiens

Alignment Length:	533	Identity:	142/533 - (26%)
Similarity:	222/533 - (41%)	Gaps:	118/533 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 MVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMI---------EMLNE 137
            :::.||:||...|.:....:.......:|.|::...:....:.|.||:..:         :::.|
Human     2 LLLLSDQLLLTALRKPNPQAMAALFLSAPPQAEVTFEDVAVYLSREEWGRLGPAQRGLYRDVMLE 66

  Fly   138 EQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMESVH 202
            ...|:.:|....|.....:.:..                |..:|...|...|...:||:.:.|
Human    67 TYGNLVSLGVGPAGPKPGVISQL----------------ERGDEPWVLDVQGTSGKEHLRVNS-- 113

  Fly   203 EFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVI--------- 258
               ||    :..:.|::.:.::|...|  .|....:.:..|..| ..:||::::::
Human   114 ---PA----LGTRTEYKELTSQETFGE--EDPQGSEPVEACDHI-SKSEGSLEKLVEQRGPRAVT 168

  Fly   259 ---GEETLELEGDGREEHLL--------PEAEDVCEDEDFLEESL-------------------- 292
               ||.:.|..|:.|   ||        |...|:|| :.|.:.|.
Human   169 LTNGESSRESGGNLR---LLSRPVPDQRPHKCDICE-QSFEQRSYLNNHKRVHRSKKTNTVRNSG 229

  Fly   293 -----------DSAPPTA--------------------------GEALPYVCTVCQKAFRQQCRL 320
                       |...||.                          .|..||.|..|.|||.|.|..
Human   230 EIFSANLVVKEDQKIPTGKKLHYCSYCGKTFRYSANLVKHQRLHTEEKPYKCDECGKAFSQSCEF 294

  Fly   321 NQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAE 385
            ..|.|.|..|..|.|:||||......|..:|...||..||::|..||:.:...|||..|:|.|..
Human   295 INHRRMHSGEIPYRCDECGKTFTRRPNLMKHQRIHTGEKPYKCGECGKHFSAYSSLIYHQRIHTG 359

  Fly   386 KKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEIC 450
            :|||.|:.||:.::....|.||:.|||||:|:.|..|.|.:..||:|.||:..|||:|.:.|..|
Human   360 EKPYKCNDCGKAFSDGSILIRHRRTHTGEKPFECKECGKGFTQSSNLIQHQRIHTGEKPYKCNEC 424

  Fly   451 GVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKR 515
            .....||:...:|...|:|.|.::|:.||..|:.:::|..|.|:|:||||:||..|.|||....|
Human   425 EKAFIQKTKLVEHQRSHTGEKPYECNDCGKVFSQSTHLIQHQRIHTGEKPYKCSECGKAFHNSSR 489

  Fly   516 LASHMRVHNKESP 528
            |..|.|:|:.|.|
Human   490 LIHHQRLHHGEKP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	3/8 (38%)
		COG5048	<297..451	CDD:227381	65/179 (36%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	57/135 (42%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
ZNF34	NP_085057.3	KRAB	35..97	CDD:214630	9/77 (12%)
		KRAB	35..74	CDD:279668	5/38 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..188		7/27 (26%)
		COG5048	188..554	CDD:227381	104/316 (33%)
		C2H2 Zn finger	197..217	CDD:275368	5/20 (25%)
		zf-C2H2	251..273	CDD:278523	0/21 (0%)
		C2H2 Zn finger	253..273	CDD:275368	0/19 (0%)
		zf-H2C2_2	265..290	CDD:290200	8/24 (33%)
		C2H2 Zn finger	281..301	CDD:275368	9/19 (47%)
		zf-C2H2	307..329	CDD:278523	8/21 (38%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		zf-H2C2_2	321..345	CDD:290200	9/23 (39%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	349..373	CDD:290200	11/23 (48%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		zf-H2C2_2	378..402	CDD:290200	12/23 (52%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		zf-H2C2_2	405..430	CDD:290200	9/24 (38%)
		C2H2 Zn finger	421..441	CDD:275368	5/19 (26%)
		zf-H2C2_2	434..458	CDD:290200	8/23 (35%)
		C2H2 Zn finger	449..469	CDD:275368	7/19 (37%)
		zf-H2C2_2	461..486	CDD:290200	14/24 (58%)
		C2H2 Zn finger	477..497	CDD:275368	9/19 (47%)
		zf-H2C2_2	493..514	CDD:290200	5/10 (50%)
		C2H2 Zn finger	505..525	CDD:275368
		zf-H2C2_2	517..542	CDD:290200
		C2H2 Zn finger	533..553	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910