DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF343

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001269426.1	Gene:	ZNF343 / 79175	HGNCID:	16017	Length:	640	Species:	Homo sapiens

Alignment Length:	524	Identity:	148/524 - (28%)
Similarity:	219/524 - (41%)	Gaps:	119/524 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 CTRACKLHKPLQEEIDLGSEGSTTLASMLNYCTGLSFEPQDGAAMPQ-HICLHCLQLLEQAFNFK 80
            |.||...|..|...   ||..|...||.:   .|::.||:     |: :.|..||    .||:.:
Human   113 CNRAISAHHNLCLP---GSSNSPATASRV---VGITAEPK-----PEIYTCSSCL----LAFSCQ 162

  Fly    81 RMVIDSDELLR--LGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQEN-- 141
            :.:  |..:|:  |||    |:   |:..|..|.|..|.:||     .::|..:....|..|.
Human   163 QFL--SQHVLQIFLGL----CA---ENHFHPGNSSPGHWKQQ-----GQQYSHVSCWFENAEGQE 213

  Fly   142 --------VANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITM 198
                    .|..:|   .|..|.|...:..                       ||...::.::.:
Human   214 RGGGSKPWSARTEE---RETSRAFPSPLQR-----------------------QSASPRKGNMVV 252

  Fly   199 ESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGE-ET 262
            |:    :|:..:.                                     |....:|:.:.| ||
Human   253 ET----EPSSAQR-------------------------------------PNPVQLDKGLKELET 276

  Fly   263 LELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSH 327
            |........|:         |.:..||.:..:.|.|.....||:|:.|.::|:.:..|.:|.|.|
Human   277 LRFGAINCREY---------EPDHNLESNFITNPRTLLGKKPYICSDCGRSFKDRSTLIRHHRIH 332

  Fly   328 VDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCD 392
            ..||.|.|.|||:......|...|..||:..||:.|..||:.:|:.|.|..|:.||:|:|||.|.
Human   333 SMEKPYVCSECGRGFSQKSNLSRHQRTHSEEKPYLCRECGQSFRSKSILNRHQWTHSEEKPYVCS 397

  Fly   393 QCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQK 457
            :||||::......||:.||:||:||.|..|.:::.|.|:||:|:..|:|:|.:.|..||.|.||.
Human   398 ECGRGFSEKSSFIRHQRTHSGEKPYVCLECGRSFCDKSTLRKHQRIHSGEKPYVCRECGRGFSQN 462

  Fly   458 SGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRV 522
            |...||...|...|.:.|..||..|...|.|..|.|.||||||:.|..|.:.|..|..|..|.|.
Human   463 SDLIKHQRTHLDEKPYVCRECGRGFCDKSTLIIHERTHSGEKPYVCGECGRGFSRKSLLLVHQRT 527

  Fly   523 HNKE 526
            |:.|
Human   528 HSGE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	20/74 (27%)
		COG5048	<297..451	CDD:227381	60/153 (39%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	58/135 (43%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
ZNF343	NP_001269426.1	KRAB	62..>102	CDD:214630
		KRAB	62..101	CDD:279668
		COG5048	307..>634	CDD:227381	92/225 (41%)
		zf-C2H2	310..332	CDD:278523	7/21 (33%)
		C2H2 Zn finger	312..332	CDD:275368	6/19 (32%)
		zf-C2H2	338..360	CDD:278523	7/21 (33%)
		C2H2 Zn finger	340..360	CDD:275368	6/19 (32%)
		zf-H2C2_2	352..377	CDD:290200	9/24 (38%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		zf-H2C2_2	381..404	CDD:290200	13/22 (59%)
		C2H2 Zn finger	396..416	CDD:275368	7/19 (37%)
		zf-H2C2_2	411..431	CDD:290200	10/19 (53%)
		zf-C2H2	422..444	CDD:278523	8/21 (38%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..461	CDD:290200	10/23 (43%)
		C2H2 Zn finger	452..472	CDD:275368	9/19 (47%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		zf-H2C2_2	493..517	CDD:290200	12/23 (52%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		zf-C2H2	534..556	CDD:278523
		C2H2 Zn finger	536..556	CDD:275368
		zf-H2C2_2	548..571	CDD:290200
		C2H2 Zn finger	564..584	CDD:275368
		zf-H2C2_2	577..601	CDD:290200
		C2H2 Zn finger	592..612	CDD:275368
		zf-H2C2_2	605..629	CDD:290200
		zf-C2H2	618..640	CDD:278523
		C2H2 Zn finger	620..640	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910