DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp354c

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_076478.1	Gene:	Zfp354c / 78972	RGDID:	69405	Length:	560	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	114/373 - (30%)
Similarity:	172/373 - (46%)	Gaps:	70/373 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDE-------VIGEETLELEGDGREEHL 274
            ::|.:.|.:::.:..::.||...........||.:..:::       ::.:||..:|......|
  Rat   130 KYERLETAQEQEKKAHEPGAASPKEVTSEDGIPTDPELEKPLFMNKALVSQETDPIERVPGMYH- 193

  Fly   275 LPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECG 339
             ...:|:.:|.| |..:....|   |:. ||||:.|.|.|.|...|.:|.|.|..||.|:|.|||
  Rat   194 -TSEKDLPQDFD-LMRNFQIYP---GQK-PYVCSECGKGFSQSLHLLEHKRIHTGEKPYKCSECG 252

  Fly   340 KRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYA----- 399
            |...|..:...|..|||..||::||.|.:.:.::|:|..|.|.|..:|||.|.:||:.::
  Rat   253 KSFSHRSSLLAHQRTHTGEKPYKCSECEKAFGSSSTLIKHLRVHTGEKPYRCRECGKAFSQCSTL 317

  Fly   400 --------------------AFD---HLRRHKLTHTGERPYACDLCDKAYYDSSSLRQH------ 435
                                ||:   .|.||:..||||:||.|..|.|.|....||.:|
  Rat   318 TVHQRIHTGEKLYKCAECDKAFNCRAKLHRHQRIHTGEKPYKCAECGKGYSQFPSLAEHQRLHTG 382

  Fly   436 --------------KIS--------HTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVC 478
                          ::|        |||:|.:.|..||...:|.|.:.:|..:|:|.|.:.|:.|
  Rat   383 GQLCQCLQCGRTFTRVSTLIEHQRIHTGQKPYQCNECGKTFNQYSSFNEHRKIHTGEKLYTCEEC 447

  Fly   479 GHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKE 526
            |.||...|||..|.|:|:||||::|..|.|||.....|..|.|:|..|
  Rat   448 GKAFGCKSNLYRHQRIHTGEKPYQCNQCGKAFSQYSFLTEHERIHTGE 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	66/209 (32%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	61/191 (32%)
		C2H2 Zn finger	391..411	CDD:275368	8/47 (17%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	8/47 (17%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
Zfp354c	NP_076478.1	KRAB	14..74	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..167		4/27 (15%)
		COG5048	208..557	CDD:227381	100/292 (34%)
		C2H2 Zn finger	220..240	CDD:275368	8/19 (42%)
		zf-H2C2_2	232..257	CDD:290200	12/24 (50%)
		C2H2 Zn finger	248..268	CDD:275368	7/19 (37%)
		zf-H2C2_2	260..283	CDD:290200	9/22 (41%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	289..313	CDD:290200	10/23 (43%)
		C2H2 Zn finger	304..324	CDD:275368	3/19 (16%)
		zf-H2C2_2	317..341	CDD:290200	2/23 (9%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		zf-H2C2_2	347..369	CDD:290200	12/21 (57%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	1/19 (5%)
		zf-H2C2_2	401..425	CDD:290200	7/23 (30%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..451	CDD:290200	7/22 (32%)
		C2H2 Zn finger	444..464	CDD:275368	10/19 (53%)
		zf-H2C2_2	456..481	CDD:290200	14/24 (58%)
		C2H2 Zn finger	472..492	CDD:275368	8/19 (42%)
		zf-H2C2_2	485..509	CDD:290200	5/11 (45%)
		C2H2 Zn finger	500..520	CDD:275368
		C2H2 Zn finger	528..547	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910