DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp449

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_084415.1	Gene:	Zfp449 / 78619	MGIID:	1925869	Length:	518	Species:	Mus musculus

Alignment Length:	538	Identity:	126/538 - (23%)
Similarity:	204/538 - (37%)	Gaps:	157/538 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RACKLHKPLQEEIDLGSEGSTTLASMLNYCTGLSFEPQDGAAMPQHICLH--CLQLLE------- 74
            |...|.:.||.|::: .|....:..||..    ...|.....||.::.|.  .||::|
Mouse   100 RVVSLIEDLQRELEI-PEPQIDMDDMLLE----ELAPVGTVPMPPNLHLEEPSLQVMEPVQEPPV 159

  Fly    75 ----------QAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEY 129
                      |..|:..              :|.|.||.:.....|......     ..|..||
Mouse   160 PDAWIPQAGPQDLNYSA--------------DAECQSFLDPGYQLPKLDMNF-----PLDHREE- 204

  Fly   130 VMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEE 194
            ..::.|.:.:|....||.::.      |.|.::.||:...|:
Mouse   205 PWVKDLEDPKEMKQLLDSKIG------FEMGIENEEDTSKEK----------------------- 240

  Fly   195 HITMESVHEFQPA-----------EVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVI 248
              .:|:::.|...           :.:||.::|::||              ...|...|...:|.
Mouse   241 --KLETLYPFVVTLEGNALHGPILQKDYVQLENQWET--------------SPEDLQTDLTKLVD 289

  Fly   249 PAEGAIDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPP---TAGEALPYVCTVC 310
            |....:.|.                  ||:..       |||.|...||   :.|:. |:.|..|
Mouse   290 PQNPTLGET------------------PESPS-------LEEPLTPKPPKKKSPGDK-PHRCPQC 328

  Fly   311 QKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSS 375
            .|.|.::.:|..|.|.|..|:.::|.|||||.....:...|...||..:|::|::|.:.:...|.
Mouse   329 GKCFARKSQLTGHQRIHSGEEPHKCPECGKRFLRSSDLYRHQRLHTGERPYECTVCKKRFTRRSH 393

  Fly   376 LAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHT 440
            |..|:|||:|::.|.|.:||:.:.....|:||..|||||:|:.|..|.|::...::|..|:.:||
Mouse   394 LLGHQRTHSEEETYKCLECGKTFCHGSSLKRHLKTHTGEKPHRCPNCGKSFSRLTALTLHQRTHT 458

  Fly   441 GKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEV 505
            .::.|                            ||..||.:|....:|..|:|:|:||||:||..
Mouse   459 EERPF----------------------------KCSYCGKSFRQRPSLVIHLRIHTGEKPYKCTH 495

  Fly   506 CVKAFPTKKRLASHMRVH 523
            |.|:|..:..|..|...|
Mouse   496 CSKSFRQRAGLIMHQVTH 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	17/90 (19%)
		COG5048	<297..451	CDD:227381	52/156 (33%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	41/135 (30%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	0/19 (0%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
Zfp449	NP_084415.1	SCAN	27..134	CDD:128708	9/38 (24%)
		SCAN	27..113	CDD:280241	5/12 (42%)
		COG5048	<323..483	CDD:227381	56/187 (30%)
		zf-C2H2	323..345	CDD:278523	7/21 (33%)
		C2H2 Zn finger	325..345	CDD:275368	7/19 (37%)
		zf-H2C2_2	341..362	CDD:290200	10/20 (50%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
		zf-H2C2_2	365..390	CDD:290200	6/24 (25%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-C2H2	407..429	CDD:278523	7/21 (33%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		zf-H2C2_2	421..446	CDD:290200	12/24 (50%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		zf-H2C2_2	449..474	CDD:290200	10/52 (19%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		zf-H2C2_2	477..502	CDD:290200	13/24 (54%)
		C2H2 Zn finger	493..513	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910