DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and PRDM2

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001380915.1	Gene:	PRDM2 / 7799	HGNCID:	9347	Length:	1718	Species:	Homo sapiens

Alignment Length:	494	Identity:	90/494 - (18%)
Similarity:	137/494 - (27%)	Gaps:	213/494 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 PAEGAIDEVIG-----EETL--------ELEGDG---REEHLLPEAEDVCEDEDFLEESLDSAPP 297
            |...||..|:.     |.:|        |||.:|   |||......:||...|.|.:.
Human  1076 PPLSAISSVVSSGDNLEASLPMISFKQEELENEGLKPREEPQSAAEQDVVVQETFNKN------- 1133

  Fly   298 TAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEH-MLTHTNVKPH 361
                   :||.||:..|.....|.:|:..|.:|..::||.|.:..|...:..|| .|.|......
Human  1134 -------FVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKDKTDLSEHRFLLHGVGNIF 1191

  Fly   362 QCSICGRFYRTTSSLAVHKR--------THAE-----KKPYNCDQCGRGYAAFDHLR-------- 405
            .||:|.:.:....:|..|:|        ||.|     .:|.|.....:.:.  :|::
Human  1192 VCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHV--EHMQSLPEDPLE 1254

  Fly   406 ----RHKLTHTGERPY------ACDLCDK---------AYYDS--------------------SS 431
                ..:|..:.|..|      |..:..|         .:|.|                    ::
Human  1255 TSKEEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATN 1319

  Fly   432 LRQHKISHTGKKAFTCEICGVGL----------------SQKSGY-------------------- 460
            ...|.|..|...|..|..||.|:                |.|..|
Human  1320 FTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVV 1384

  Fly   461 ---------------------------------------KKHMMVHSGV---------------- 470
                                                   ||:.:|...:
Human  1385 VLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKNA 1449

  Fly   471 ---KAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVT-- 530
               .:|.|..|...||:..:||.|......:||..        |.||:::...:.....||.:
Human  1450 CESSSHICPYCNREFTYIGSLNKHAAFSCPKKPLS--------PPKKKVSHSSKKGGHSSPASSD 1506

  Fly   531 -------------ATVAVQSINPPSRQAGAEGATGGGAT 556
                         |.:.:||:..|   .|...|...|.|
Human  1507 KNSNSNHRRRTADAEIKMQSMQTP---LGKTRARSSGPT 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	41/214 (19%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	7/20 (35%)
		C2H2 Zn finger	363..383	CDD:275368	6/27 (22%)
		COG5048	<387..523	CDD:227381	37/276 (13%)
		C2H2 Zn finger	391..411	CDD:275368	2/31 (6%)
		zf-H2C2_2	403..426	CDD:290200	6/49 (12%)
		C2H2 Zn finger	419..439	CDD:275368	5/48 (10%)
		C2H2 Zn finger	447..467	CDD:275368	9/94 (10%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	5/22 (23%)
		C2H2 Zn finger	503..523	CDD:275368	3/19 (16%)
PRDM2	NP_001380915.1	PR-SET_PRDM2	23..145	CDD:380965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..335
		Retinoblastoma protein binding	294..316
		zf-C2H2	360..382	CDD:395048
		C2H2 Zn finger	362..382	CDD:275370
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..457
		zf-C2H2_4	483..506	CDD:404733
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..550
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..660
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	729..797
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..1083		3/6 (50%)
		SH3-binding. /evidence=ECO:0000255	970..979
		SH3-binding. /evidence=ECO:0000255	985..998
		SH3-binding. /evidence=ECO:0000255	1028..1052
		C2H2 Zn finger	1136..1156	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1164..1185	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1193..1211	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1244..1265		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1478..1576		15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1589..1612
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1625..1652
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910