DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF229

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_055333.3	Gene:	ZNF229 / 7772	HGNCID:	13022	Length:	825	Species:	Homo sapiens

Alignment Length:	225	Identity:	104/225 - (46%)
Similarity:	131/225 - (58%)	Gaps:	0/225 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGR 368
            ||||.||.|.|.....|..|.|.|..||.|:|.||||...:......|...||..||::|..||:
Human   599 PYVCDVCGKGFIYSSDLLIHQRVHTGEKPYKCAECGKGFSYSSGLLIHQRVHTGEKPYRCQECGK 663

  Fly   369 FYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLR 433
            .:|.||||..|:|.|..||||.|||||:|::...:||.|:..||||:||.|..|.|.:...|.|.
Human   664 GFRCTSSLHKHQRVHTGKKPYTCDQCGKGFSYGSNLRTHQRLHTGEKPYTCCECGKGFRYGSGLL 728

  Fly   434 QHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGE 498
            .||..|||:|.:.|.:||.|.||.|..:.|..||:|.|.:||:.||..|...|.|:.|.|:|:||
Human   729 SHKRVHTGEKPYRCHVCGKGYSQSSHLQGHQRVHTGEKPYKCEECGKGFGRNSCLHVHQRVHTGE 793

  Fly   499 KPFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            ||:.|.||.|.|.....|.:|.|||..|:|
Human   794 KPYTCGVCGKGFSYTSGLRNHQRVHLGENP 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	67/146 (46%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	10/19 (53%)
		COG5048	<387..523	CDD:227381	63/135 (47%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZNF229	NP_055333.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		KRAB	34..>74	CDD:214630
		KRAB	34..73	CDD:279668
		C2H2 Zn finger	351..371	CDD:275368
		COG5048	375..787	CDD:227381	85/187 (45%)
		C2H2 Zn finger	379..399	CDD:275368
		zf-H2C2_2	391..416	CDD:290200
		C2H2 Zn finger	407..427	CDD:275368
		zf-H2C2_2	420..442	CDD:290200
		C2H2 Zn finger	435..455	CDD:275368
		C2H2 Zn finger	463..483	CDD:275368
		zf-H2C2_2	475..500	CDD:290200
		C2H2 Zn finger	491..511	CDD:275368
		C2H2 Zn finger	519..539	CDD:275368
		C2H2 Zn finger	547..566	CDD:275368
		zf-H2C2_2	562..583	CDD:290200
		C2H2 Zn finger	574..594	CDD:275368
		zf-H2C2_2	589..611	CDD:290200	8/11 (73%)
		C2H2 Zn finger	602..622	CDD:275368	8/19 (42%)
		zf-H2C2_2	614..639	CDD:290200	12/24 (50%)
		C2H2 Zn finger	630..650	CDD:275368	6/19 (32%)
		zf-H2C2_2	643..667	CDD:290200	8/23 (35%)
		C2H2 Zn finger	658..678	CDD:275368	10/19 (53%)
		zf-H2C2_2	673..695	CDD:290200	13/21 (62%)
		C2H2 Zn finger	686..706	CDD:275368	9/19 (47%)
		zf-H2C2_2	698..723	CDD:290200	12/24 (50%)
		C2H2 Zn finger	714..734	CDD:275368	7/19 (37%)
		zf-H2C2_2	727..751	CDD:290200	11/23 (48%)
		C2H2 Zn finger	742..762	CDD:275368	8/19 (42%)
		zf-H2C2_2	754..779	CDD:290200	10/24 (42%)
		C2H2 Zn finger	770..790	CDD:275368	8/19 (42%)
		zf-H2C2_2	785..807	CDD:290200	12/21 (57%)
		C2H2 Zn finger	798..818	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910