DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF195

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001123992.1	Gene:	ZNF195 / 7748	HGNCID:	12986	Length:	629	Species:	Homo sapiens

Alignment Length:	613	Identity:	180/613 - (29%)
Similarity:	246/613 - (40%)	Gaps:	174/613 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TRACKLHKPLQEEIDLGSEGSTTLASMLNYCTGLSFEPQDG------------------------ 58
            |:||.       |: |||......||.....||::...|.|
Human    83 TQACL-------EL-LGSSDLPASASQSAGITGVNHRAQPGLNVSVDKFTALCSPGVLQTVKWFL 139

  Fly    59 -------AAMPQHICLHCL--QLLEQAFNFKRMV-------IDSDELLR--LGLDEAR------- 98
                   .||..|.....|  |.::.||. ||::       :|:..|.:  ..|||.:
Human   140 EFRCIFSLAMSSHFTQDLLPEQGIQDAFP-KRILRGYGNCGLDNLYLRKDWESLDECKLQKDYNG 203

  Fly    99 ---CSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDEE--LAEEDRRIFA 158
               ||    |.|||  :..|:::..:.||:        ..|..:.|::|..|:  ..:|..:.|.
Human   204 LNQCS----STTHS--KIFQYNKYVKIFDN--------FSNLHRRNISNTGEKPFKCQECGKSFQ 254

  Fly   159 MTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQ------------QEEHITMESVHEFQPAEVEY 211
            |.     .|||            |||...:|.:            |..|.|
Human   255 ML-----SFLT------------EHQKIHTGKKFQKCGECGKTFIQCSHFT-------------- 288

  Fly   212 VTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGR------ 270
                 |.|.|.|.|..::...   .::.|..|.::   .:..|  ..|.|....|..|:
Human   289 -----EPENIDTGEKPYKCQE---CNNVIKTCSVL---TKNRI--YAGGEHYRCEEFGKVFNQCS 340

  Fly   271 --EEHLLPEAEDVCEDED----FLE-ESLDSAPP-TAGEAL------------------------ 303
              .||.....|..|:.|:    |:. .||.:... .|||.|
Human   341 HLTEHEHGTEEKPCKYEECSSVFISCSSLSNQQMILAGEKLSKCETWYKGFNHSPNPSKHQRNEI 405

  Fly   304 ---PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSI 365
               |:.|..|...|:....|.:|.|.|..||.|:|:||||......:..||...||..||:||..
Human   406 GGKPFKCEECDSIFKWFSDLTKHKRIHTGEKPYKCDECGKAYTQSSHLSEHRRIHTGEKPYQCEE 470

  Fly   366 CGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSS 430
            ||:.:||.|||:.|||||:|:|||.|::||..:.....|.:||.|||||:||.||.|.|.:..||
Human   471 CGKVFRTCSSLSNHKRTHSEEKPYTCEECGNIFKQLSDLTKHKKTHTGEKPYKCDECGKNFTQSS 535

  Fly   431 SLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLH 495
            :|..||..|||:|.:.||.||......|...||...|:|.|.:|||.||..||.:|||..|.|:|
Human   536 NLIVHKRIHTGEKPYKCEECGRVFMWFSDITKHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIH 600

  Fly   496 SGEKPFKCEVCVKAFPTKKRLASHMRVH 523
            :||||:|||.|.|||.....|..|..:|
Human   601 TGEKPYKCEKCGKAFTQFSHLTVHESIH 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	24/112 (21%)
		COG5048	<297..451	CDD:227381	72/181 (40%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	11/19 (58%)
		COG5048	<387..523	CDD:227381	65/135 (48%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	14/22 (64%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	11/19 (58%)
		zf-H2C2_2	487..510	CDD:290200	14/22 (64%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZNF195	NP_001123992.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		Spacer	76..243		40/182 (22%)
		COG5048	225..629	CDD:227381	146/456 (32%)
		C2H2 Zn finger	246..266	CDD:275368	9/36 (25%)
		C2H2 Zn finger	274..294	CDD:275368	5/38 (13%)
		C2H2 Zn finger	302..345	CDD:275368	7/50 (14%)
		C2H2 Zn finger	384..404	CDD:275368	0/19 (0%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		zf-H2C2_2	424..449	CDD:290200	12/24 (50%)
		C2H2 Zn finger	440..460	CDD:275368	7/19 (37%)
		zf-H2C2_2	452..477	CDD:290200	10/24 (42%)
		C2H2 Zn finger	468..488	CDD:275368	11/19 (58%)
		zf-H2C2_2	480..505	CDD:290200	14/24 (58%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		zf-H2C2_2	508..533	CDD:290200	14/24 (58%)
		C2H2 Zn finger	524..544	CDD:275368	9/19 (47%)
		zf-H2C2_2	536..559	CDD:290200	11/22 (50%)
		C2H2 Zn finger	552..572	CDD:275368	7/19 (37%)
		zf-H2C2_2	567..589	CDD:290200	11/21 (52%)
		C2H2 Zn finger	580..600	CDD:275368	11/19 (58%)
		zf-H2C2_2	592..617	CDD:290200	16/24 (67%)
		C2H2 Zn finger	608..628	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100