DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF180

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_037388.3	Gene:	ZNF180 / 7733	HGNCID:	12970	Length:	692	Species:	Homo sapiens

Alignment Length:	591	Identity:	148/591 - (25%)
Similarity:	241/591 - (40%)	Gaps:	118/591 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DLGSEGSTTLASMLNYCTGLSFEPQD------------GAAMPQHICLH-------CLQL-LEQA 76
            :.|| |:..|:::|  |...|.|.||            .:.:||.|.:.       .|.: .::.
Human    10 EAGS-GAQDLSTLL--CLEESMEEQDEKPPEPPKVCAQDSFLPQEIIIKVEGEDTGSLTIPSQEG 71

  Fly    77 FNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQEN 141
            .|||.:.:|                |...:..:.|.:|:...:....::..:.|..::.....:.
Human    72 VNFKIVTVD----------------FTREEQGTCNPAQRTLDRDVILENHRDLVSWDLATAVGKK 120

  Fly   142 VANLDEELAEEDR----RIFAMTVDEEEEFLTEEVDQ-DDELSEEE------------------- 182
            .:...:.:.:|:.    :|...|.|:......||||. .|:|.:::
Human   121 DSTSKQRIFDEEPANGVKIERFTRDDPWLSSCEEVDDCKDQLEKQQEKQEILLQEVAFTQRKAVI 185

  Fly   183 HQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIV 247
            |:.....|:..|...:.|.....|.    :.|:|.|...|:...::.:.....:|..|.:.:.:.
Human   186 HERVCKSDETGEKSGLNSSLFSSPV----IPIRNHFHKHVSHAKKWHLNAAVNSHQKINENETLY 246

  Fly   248 IPAE-----------------------GAIDEVI----------------GEETLELEGDGR--- 270
            ...|                       |..|.:.                |.:|.:.:..|:
Human   247 ENNECGKPPQSIHLIQFTRTQTKDKSYGFSDRIQSFCHGTPLHIHEKIHGGGKTFDFKECGQVLN 311

  Fly   271 ------EEHLLP--EAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSH 327
                  |:..:|  |::..|.:... ..||........|..|:.|..|.|:|.....|..|.|:|
Human   312 PKISHNEQQRIPFEESQYKCSETSH-SSSLTQNMRNNSEEKPFECNQCGKSFSWSSHLVAHQRTH 375

  Fly   328 VDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCD 392
            ..||.|||.||||......:...|..|||..||::|:.||:.:..:..|.||:|||..:|||.|:
Human   376 TGEKPYECSECGKSFSRSSHLVSHQRTHTGEKPYRCNQCGKSFSQSYVLVVHQRTHTGEKPYECN 440

  Fly   393 QCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQK 457
            |||:.:.....|..|:.|||||:||.|:.|.|::..|..|..|:..|||:|.:.|..||...||.
Human   441 QCGKSFRQSYKLIAHQRTHTGEKPYECNQCGKSFIQSYKLIAHQRIHTGEKPYECNQCGKSFSQS 505

  Fly   458 SGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRV 522
            .....|...|:|.|..:|:.||.:|:::|.|.||.|.|:||||::|..|.|:|.....|..|.|:
Human   506 YKLVAHQRTHTGEKPFECNQCGKSFSWSSQLVAHQRTHTGEKPYECSECGKSFNRSSHLVMHQRI 570

  Fly   523 HNKESP 528
            |..|.|
Human   571 HTGEKP 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	18/78 (23%)
		COG5048	<297..451	CDD:227381	61/153 (40%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	56/135 (41%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
ZNF180	NP_037388.3	KRAB	72..133	CDD:214630	9/76 (12%)
		KRAB	72..111	CDD:279668	8/54 (15%)
		C2H2 Zn finger	249..267	CDD:275368	1/17 (6%)
		C2H2 Zn finger	275..295	CDD:275368	1/19 (5%)
		COG5048	332..692	CDD:227381	95/246 (39%)
		C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		zf-H2C2_2	367..392	CDD:290200	13/24 (54%)
		C2H2 Zn finger	383..403	CDD:275368	6/19 (32%)
		zf-H2C2_2	395..420	CDD:290200	9/24 (38%)
		C2H2 Zn finger	411..431	CDD:275368	7/19 (37%)
		zf-H2C2_2	424..448	CDD:290200	13/23 (57%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		zf-H2C2_2	455..476	CDD:290200	11/20 (55%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		zf-H2C2_2	483..504	CDD:290200	8/20 (40%)
		C2H2 Zn finger	495..515	CDD:275368	6/19 (32%)
		zf-H2C2_2	508..531	CDD:290200	7/22 (32%)
		C2H2 Zn finger	523..543	CDD:275368	9/19 (47%)
		zf-H2C2_2	536..560	CDD:290200	13/23 (57%)
		C2H2 Zn finger	551..571	CDD:275368	7/19 (37%)
		zf-H2C2_2	563..588	CDD:290200	6/14 (43%)
		C2H2 Zn finger	579..599	CDD:275368
		zf-H2C2_2	592..616	CDD:290200
		C2H2 Zn finger	607..627	CDD:275368
		zf-H2C2_2	620..643	CDD:290200
		C2H2 Zn finger	635..655	CDD:275368
		zf-H2C2_2	648..670	CDD:290200
		C2H2 Zn finger	663..683	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910