DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and ZBTB16

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001018011.1	Gene:	ZBTB16 / 7704	HGNCID:	12930	Length:	673	Species:	Homo sapiens

Alignment Length:	631	Identity:	134/631 - (21%)
Similarity:	210/631 - (33%)	Gaps:	185/631 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ICLHCLQLLEQAFNFKRMVIDSDELLRLGLDEARCSS------FHESQTH------SPNQSQQHD 117
            :|...:.:..|.|:..|.|:             .|:|      ||.:..|      ||
Human    33 LCDVVIMVDSQEFHAHRTVL-------------ACTSKMFEILFHRNSQHYTLDFLSP------- 77

  Fly   118 QQQQAFDSTEEYVMIEMLNEEQENVAN-------LDEELAEEDRRIFAMTVDEEEEFLTEEVDQD 175
               :.|....||.....|..:.|::.:       |:.|..||.......|:...::..||....|
Human    78 ---KTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLETIQASDDNDTEATMAD 139

  Fly   176 DELSEEE--------------HQLAQSG--------------DQQEEHITMESVHEFQPAEVEYV 212
            ....|||              |...:||              ||.....|...:....|.:....
Human   140 GGAEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVD 204

  Fly   213 TIKNEFETIV------TEEDEFEVMNDSGAHDAILD-----CQMIVIP-------AEGAIDEVIG 259
            ::....::::      ....|...:...|.|..:.:     .|:..:|       ||.:|...:|
Human   205 SLMTIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAEVKTEMMQVDEVPSQDSPGAAESSISGGMG 269

  Fly   260 EETLELEGDGREEHLLPEAEDVCEDEDFL----EESLDSAPP----------------------- 297
            :   ::|..|:|....|....|......|    |||.:..||
Human   270 D---KVEERGKEGPGTPTRSSVITSARELHYGREESAEQVPPPAEAGQAPTGRPEHPAPPPEKHL 331

  Fly   298 --------------------------------------TAGEALPY------------------- 305
                                                  |.|..||.
Human   332 GIYSVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMK 396

  Fly   306 --------VCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHT-NVKPH 361
                    .|:||.........:.||.:.|...|.|.||.||||.......:.|:|.|: ..|..
Human   397 SESRTIGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAF 461

  Fly   362 QCSICGRFYRTTSSLAVHKRTH-AEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKA 425
            .|..||..:....:|..|::|| .......|..||:.:.|...|::|...|.|.|.|.|..|::.
Human   462 VCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRT 526

  Fly   426 YYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNA 490
            :...::|::|..||||...:.||.||.....:|..|.|..:|:|.|.::|:.||..|:....|..
Human   527 FPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLET 591

  Fly   491 HVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAVQ 536
            |.|:|:|||||:|::|.:.......:..|:|.||..||...|:..:
Human   592 HYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTE 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	5/25 (20%)
		COG5048	<297..451	CDD:227381	50/243 (21%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		COG5048	<387..523	CDD:227381	45/135 (33%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	8/22 (36%)
		C2H2 Zn finger	419..439	CDD:275368	4/19 (21%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	4/19 (21%)
ZBTB16	NP_001018011.1	BTB	25..125	CDD:306997	21/114 (18%)
		Herpes_ICP4_C	177..>327	CDD:332854	24/152 (16%)
		Interaction with RUNX1T1. /evidence=ECO:0000269\|PubMed:10688654	200..300		15/102 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..236		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..332		16/85 (19%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		COG5048	<448..622	CDD:227381	55/173 (32%)
		C2H2 Zn finger	463..483	CDD:275368	5/19 (26%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	4/19 (21%)
		C2H2 Zn finger	548..568	CDD:275368	7/19 (37%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		C2H2 Zn finger	604..624	CDD:275368	4/19 (21%)
		C2H2 Zn finger	632..652	CDD:275368	1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910