DRSC/TRiP Functional Genomics Resources

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Protein Alignment dwg and ZNF136

DIOPT Version :9

Sequence 1:NP_477338.3 Gene:dwg / 31265 FlyBaseID:FBgn0000520 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_003428.1 Gene:ZNF136 / 7695 HGNCID:12920 Length:540 Species:Homo sapiens


Alignment Length:283 Identity:106/283 - (37%)
Similarity:146/283 - (51%) Gaps:16/283 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   304 PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGR 368
            ||.|.||.|||....|...|.|||..||.|||:||||....:.:.:.||:.||...|::|.:||:
Human   195 PYKCKVCGKAFDYPSRFRTHERSHTGEKPYECQECGKAFTCITSVRRHMIKHTGDGPYKCKVCGK 259

  Fly   369 FYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLR 433
            .:.:.||..||:|.|..:||:.|.|||:.::....||.|:.|||||:||.|..|.||:....|||
Human   260 PFHSLSSFQVHERIHTGEKPFKCKQCGKAFSCSPTLRIHERTHTGEKPYECKQCGKAFSYLPSLR 324

  Fly   434 QHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGE 498
            .|:..|||:|.|.|:.||......|.::.|...|:|.|.::|..||.||:...::..|:..|:||
Human   325 LHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGE 389

  Fly   499 KPFKCEVCVKAFPTKKRLASHMRVHNKESPVT------ATVAVQSINPPSRQAGAEGATGGGATG 557
            .|:||:||.|.|.:......|.|.|..|.|..      |.|:..||....|.          .||
Human   390 GPYKCKVCGKPFHSLSPFRIHERTHTGEKPYVCKHCGKAFVSSTSIRIHERT----------HTG 444

  Fly   558 GSPTGGGATGGSATNLHITEVHE 580
            ..|......|.:.:.|:....||
Human   445 EKPYECKQCGKAFSYLNSFRTHE 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dwgNP_477338.3 zf-AD 14..91 CDD:214871
COG5048 <297..451 CDD:227381 66/146 (45%)
C2H2 Zn finger 307..327 CDD:275368 9/19 (47%)
C2H2 Zn finger 335..355 CDD:275368 7/19 (37%)
C2H2 Zn finger 363..383 CDD:275368 8/19 (42%)
COG5048 <387..523 CDD:227381 55/135 (41%)
C2H2 Zn finger 391..411 CDD:275368 7/19 (37%)
zf-H2C2_2 403..426 CDD:290200 13/22 (59%)
C2H2 Zn finger 419..439 CDD:275368 8/19 (42%)
C2H2 Zn finger 447..467 CDD:275368 5/19 (26%)
C2H2 Zn finger 475..495 CDD:275368 6/19 (32%)
zf-H2C2_2 487..510 CDD:290200 10/22 (45%)
C2H2 Zn finger 503..523 CDD:275368 7/19 (37%)
ZNF136NP_003428.1 KRAB 3..44 CDD:307490
C2H2 Zn finger 143..162 CDD:275368
COG5048 157..526 CDD:227381 106/283 (37%)
C2H2 Zn finger 170..190 CDD:275368
C2H2 Zn finger 198..218 CDD:275368 9/19 (47%)
C2H2 Zn finger 226..246 CDD:275368 7/19 (37%)
C2H2 Zn finger 254..274 CDD:275368 8/19 (42%)
C2H2 Zn finger 282..302 CDD:275368 7/19 (37%)
C2H2 Zn finger 310..330 CDD:275368 8/19 (42%)
C2H2 Zn finger 338..358 CDD:275368 5/19 (26%)
C2H2 Zn finger 366..386 CDD:275368 6/19 (32%)
C2H2 Zn finger 394..414 CDD:275368 7/19 (37%)
C2H2 Zn finger 422..442 CDD:275368 5/29 (17%)
C2H2 Zn finger 450..470 CDD:275368 4/18 (22%)
C2H2 Zn finger 478..498 CDD:275368
C2H2 Zn finger 506..526 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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