DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF90

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_009069.1	Gene:	ZNF90 / 7643	HGNCID:	13165	Length:	601	Species:	Homo sapiens

Alignment Length:	534	Identity:	146/534 - (27%)
Similarity:	240/534 - (44%)	Gaps:	98/534 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ICLHCLQLL--EQAF--NFKRMVIDSDELLRLGLDEAR--CSSFHESQTHSPNQSQQHDQQQQAF 123
            :|.|..|.|  ||:.  :|:::::...|....|..|.:  |.|..|.:.|    .:.::...|..
Human    77 MCFHFAQDLCPEQSLKDSFQKVIVTRYEKREYGNLELKKGCESVDEGKVH----KRGYNGLNQCL 137

  Fly   124 DSTEE-------YVMIEML--NEEQENVANLDEELAE--EDRRIF--AMTVDEEEEFLTEEVD-Q 174
            .:|:.       ||.:..:  |..:..:.:..::..:  |..:.|  :.|:...::..|.|:. :
Human   138 TATQSKVFQCDTYVKVSHIFSNSNRHKIRDTGKKPFKCIECGKAFNQSSTLATHKKIHTGEITCK 202

  Fly   175 DDELSEEEHQLAQSGDQQEEHITMESVHEFQPA--EVEYVTIKNEFETIVTEEDEFEVMNDSG-- 235
            .:|..:..::.:.....:..| |.|..::.:..  |::|.:.....:.|.|.|..:: ..|.|
Human   203 CEECGKAFNRSSHLTSHKRIH-TGEKRYKCEDCGKELKYSSTLTAHKRIHTGEKRYK-CEDCGKE 265

  Fly   236 --------AHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGRE--------EHLLPEAED---V 281
                    ||..|                ..||:..:.:..||.        .|.:...|:   .
Human   266 LKYSSTLTAHKRI----------------HTGEKPYKCDKCGRAFISSSILYVHKISHTEEKPYK 314

  Fly   282 CED--EDFLEESLDSAPPT--AGEALPYVCTVCQKAFRQQCRLNQHMR----------------- 325
            ||:  :.|...|:.|....  .||. ||.|..|.||||:...|..|.|
Human   315 CEECGKAFKLSSILSTHKRIHTGEK-PYKCEECGKAFRRSLVLRTHKRIHTGEKPYKCDKCGKAF 378

  Fly   326 -----------SHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVH 379
                       ||.::|.|:||||||..|.......|.::||..||::|..|.:.::.:|:|:.|
Human   379 ISSSLLYKHKISHSEKKPYKCEECGKAFKRSSTLTIHKISHTEEKPYKCQECDKVFKRSSALSTH 443

  Fly   380 KRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKA 444
            |..|:.:|||.|::||:.:....:|..||::||.|:.|.|..||||:..||:|..|||.|:|:..
Human   444 KIIHSGEKPYKCEECGKAFKRSSNLTTHKISHTEEKLYKCQECDKAFKYSSALSTHKIIHSGENP 508

  Fly   445 FTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKA 509
            :.||.||....:.|...||.::|:|.|.:||:.||.||..:|.|.:|...|:||||:|||.|.||
Human   509 YKCEECGKAFKRSSVLSKHKIIHTGAKPYKCEECGKAFKRSSQLTSHKISHTGEKPYKCEECGKA 573

  Fly   510 FPTKKRLASHMRVH 523
            |.....|.:|.|:|
Human   574 FNLSSDLNTHKRIH 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	8/29 (28%)
		COG5048	<297..451	CDD:227381	64/183 (35%)
		C2H2 Zn finger	307..327	CDD:275368	9/47 (19%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	60/135 (44%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	11/19 (58%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
ZNF90	NP_009069.1	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		COG5048	170..501	CDD:227381	88/349 (25%)
		C2H2 Zn finger	175..195	CDD:275368	3/19 (16%)
		C2H2 Zn finger	203..223	CDD:275368	1/19 (5%)
		C2H2 Zn finger	231..251	CDD:275368	2/19 (11%)
		C2H2 Zn finger	259..279	CDD:275368	5/35 (14%)
		zf-H2C2_2	272..296	CDD:290200	7/39 (18%)
		C2H2 Zn finger	287..307	CDD:275368	3/19 (16%)
		zf-H2C2_2	300..323	CDD:290200	4/22 (18%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		zf-H2C2_2	328..352	CDD:290200	10/24 (42%)
		C2H2 Zn finger	343..363	CDD:275368	9/19 (47%)
		zf-H2C2_2	356..380	CDD:290200	3/23 (13%)
		C2H2 Zn finger	371..391	CDD:275368	0/19 (0%)
		C2H2 Zn finger	399..419	CDD:275368	8/19 (42%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		zf-H2C2_2	439..464	CDD:290200	10/24 (42%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		C2H2 Zn finger	483..503	CDD:275368	11/19 (58%)
		zf-H2C2_2	495..520	CDD:290200	10/24 (42%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		zf-H2C2_2	524..548	CDD:290200	11/23 (48%)
		C2H2 Zn finger	539..559	CDD:275368	8/19 (42%)
		zf-H2C2_2	552..575	CDD:290200	13/22 (59%)
		C2H2 Zn finger	567..587	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010