DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF16

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001025147.2	Gene:	ZNF16 / 7564	HGNCID:	12947	Length:	682	Species:	Homo sapiens

Alignment Length:	492	Identity:	152/492 - (30%)
Similarity:	228/492 - (46%)	Gaps:	86/492 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 CSSFHESQTHSPNQSQQHDQQQQAFDSTE--EYVMIEMLNEEQENVANLDEELAEEDRRIFAMTV 161
            |.|..|.:...|     |.||......||  |::..|.::|:.|:.|.:.|.        :|..|
Human    49 CCSDTELEAICP-----HYQQPDCDTRTEDKEFLHKEDIHEDLESQAEISEN--------YAGDV 100

  Fly   162 DEEEEF--LTEEVDQDDELSEEEHQLAQSGDQQEEHITMESVHEFQPAEV--------EYVTIKN 216
            .:..|.  |.::|.:.|....|..:|.||..|:         .:|.||.:        |.....|
Human   101 SQVPELGDLCDDVSERDWGVPEGRRLPQSLSQE---------GDFTPAAMGLLRGPLGEKDLDCN 156

  Fly   217 EFET-------------IVTEE--DEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGE--ETLE 264
            .|::             |.|||  ..:::...|..|...|.....|..||..:  :..|  :|.:
Human   157 GFDSRFSLSPNLMACQEIPTEERPHPYDMGGQSFQHSVDLTGHEGVPTAESPL--ICNECGKTFQ 219

  Fly   265 LEGDGREEHLL--PEAEDVCED--EDFLEESL----------DSAPPTA--GEAL---------- 303
            ...|..:..::  .||..:|:|  :.|.:.|:          :.|...:  |:|.
Human   220 GNPDLIQRQIVHTGEASFMCDDCGKTFSQNSVLKNRHRSHMSEKAYQCSECGKAFRGHSDFSRHQ 284

  Fly   304 -------PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPH 361
                   ||:|..|.|||.|...|.:|.:||:.||.|||.||||..:...|..:|...|:..||:
Human   285 SHHSSERPYMCNECGKAFSQNSSLKKHQKSHMSEKPYECNECGKAFRRSSNLIQHQRIHSGEKPY 349

  Fly   362 QCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAY 426
            .||.||:.:|.:|:|..|.|||..:||:.|.:||:.::...|||:|:..||||:||.|:.|.|.:
Human   350 VCSECGKAFRRSSNLIKHHRTHTGEKPFECGECGKAFSQSAHLRKHQRVHTGEKPYECNDCGKPF 414

  Fly   427 YDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAH 491
            ...|:|.:|...|||:|.:.|..||...||.|...:|..:|:|.|.|.|:|||.||:::|.|..|
Human   415 SRVSNLIKHHRVHTGEKPYKCSDCGKAFSQSSSLIQHRRIHTGEKPHVCNVCGKAFSYSSVLRKH 479

  Fly   492 VRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            ..:|:||||::|.||.|||.....|..|..||..:.|
Human   480 QIIHTGEKPYRCSVCGKAFSHSSALIQHQGVHTGDKP 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	65/172 (38%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	9/19 (47%)
		COG5048	<387..523	CDD:227381	58/135 (43%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	13/22 (59%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZNF16	NP_001025147.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Necessary for transcription activation	62..210		37/166 (22%)
		COG5048	<160..369	CDD:227381	56/210 (27%)
		C2H2 Zn finger	187..203	CDD:275368	3/15 (20%)
		C2H2 Zn finger	211..231	CDD:275368	3/19 (16%)
		C2H2 Zn finger	239..259	CDD:275368	4/19 (21%)
		C2H2 Zn finger	267..287	CDD:275368	2/19 (11%)
		Required for nuclear localization	268..393		45/124 (36%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		COG5048	303..675	CDD:227381	91/214 (43%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		Required for nuclear localization	341..373		14/31 (45%)
		C2H2 Zn finger	351..371	CDD:275368	9/19 (47%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	407..427	CDD:275368	6/19 (32%)
		C2H2 Zn finger	435..455	CDD:275368	7/19 (37%)
		C2H2 Zn finger	463..483	CDD:275368	9/19 (47%)
		Required for nuclear localization	473..503		14/29 (48%)
		C2H2 Zn finger	491..511	CDD:275368	8/19 (42%)
		C2H2 Zn finger	519..539	CDD:275368
		C2H2 Zn finger	547..567	CDD:275368
		C2H2 Zn finger	575..595	CDD:275368
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910