DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF12

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_057349.2	Gene:	ZNF12 / 7559	HGNCID:	12902	Length:	697	Species:	Homo sapiens

Alignment Length:	469	Identity:	131/469 - (27%)
Similarity:	208/469 - (44%)	Gaps:	82/469 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 QQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTE----------EV 172
            ::.|..|..::....:::.|...|:.::...:.:.|  :.:.....||.::.|          ||
Human    20 EEWQQLDPEQKITYRDVMLENYSNLVSVGYHIIKPD--VISKLEQGEEPWIVEGEFLLQSYPDEV 82

  Fly   173 DQDDEL----SEEEHQ-----------LAQSGDQQEEHITMESVHEFQPAEVEYVTIKNEF---- 218
            .|.|:|    .|||::           :.:.|:...:...:|:    .|.....:..||..
Human    83 WQTDDLIERIQEEENKPSRQTVFIETLIEERGNVPGKTFDVET----NPVPSRKIAYKNSLCDSC 143

  Fly   219 ETIVTEEDEFEVMNDSGAHDAILDC-----QMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEA 278
            |..:|...|:...:.|.|.....:|     .::.|..|....   |::..|...:| |.:.|.|
Human   144 EKCLTSVSEYISSDGSYARMKADECSGCGKSLLHIKLEKTHP---GDQAYEFNQNG-EPYTLNE- 203

  Fly   279 EDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFR------------------------QQCR 319
            |.:.:....||:             |:....|||||:                        |...
Human   204 ESLYQKIRILEK-------------PFEYIECQKAFQKDTVFVNHMEEKPYKWNGSEIAFLQMSD 255

  Fly   320 LNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHA 384
            |..|..||::.|.|||.||||.......:..|..|||..||::|:.||:.:....:|.||:|||.
Human   256 LTVHQTSHMEMKPYECSECGKSFCKKSKFIIHQRTHTGEKPYECNQCGKSFCQKGTLTVHQRTHT 320

  Fly   385 EKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEI 449
            .:|||.|::||:.:....||.:|:.||:||:||.|..|.|::...:.|.||:.:|:|::.:.|..
Human   321 GEKPYECNECGKNFYQKLHLIQHQRTHSGEKPYECSYCGKSFCQKTHLTQHQRTHSGERPYVCHD 385

  Fly   450 CGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKK 514
            ||...||||....|..:|:|||.:||..||..|...|.|..|:|.|:||||::|..|.|.|....
Human   386 CGKTFSQKSALNDHQKIHTGVKLYKCSECGKCFCRKSTLTTHLRTHTGEKPYECNECGKFFSRLS 450

  Fly   515 RLASHMRVHNKESP 528
            .|..|.|.|:.|.|
Human   451 YLTVHYRTHSGEKP 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	58/177 (33%)
		C2H2 Zn finger	307..327	CDD:275368	8/43 (19%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	56/135 (41%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
ZNF12	NP_057349.2	KRAB	8..68	CDD:214630	7/49 (14%)
		KRAB	8..47	CDD:279668	4/26 (15%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..306	CDD:290200	9/18 (50%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		COG5048	307..683	CDD:227381	65/158 (41%)
		zf-H2C2_2	312..334	CDD:290200	12/21 (57%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-H2C2_2	339..362	CDD:290200	12/22 (55%)
		C2H2 Zn finger	355..375	CDD:275368	6/19 (32%)
		zf-H2C2_2	367..392	CDD:290200	8/24 (33%)
		C2H2 Zn finger	383..403	CDD:275368	8/19 (42%)
		C2H2 Zn finger	439..459	CDD:275368	7/19 (37%)
		zf-H2C2_2	451..474	CDD:290200	6/14 (43%)
		C2H2 Zn finger	467..487	CDD:275368
		zf-H2C2_2	479..504	CDD:290200
		C2H2 Zn finger	495..515	CDD:275368
		C2H2 Zn finger	523..543	CDD:275368
		zf-H2C2_2	538..560	CDD:290200
		C2H2 Zn finger	551..571	CDD:275368
		zf-H2C2_2	563..586	CDD:290200
		zf-C2H2	577..599	CDD:278523
		C2H2 Zn finger	579..599	CDD:275368
		zf-H2C2_2	591..616	CDD:290200
		C2H2 Zn finger	607..627	CDD:275368
		zf-H2C2_2	619..644	CDD:290200
		C2H2 Zn finger	635..655	CDD:275368
		zf-H2C2_2	647..670	CDD:290200
		C2H2 Zn finger	663..683	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910