DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZIC3

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_003404.1	Gene:	ZIC3 / 7547	HGNCID:	12874	Length:	467	Species:	Homo sapiens

Alignment Length:	165	Identity:	52/165 - (31%)
Similarity:	79/165 - (47%)	Gaps:	19/165 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 CQKAFRQQCRLNQHM-RSHV---DEKQYEC--EEC---GKRLKHLRNYKEHMLTHTNVKPHQCSI 365
            |.:.|.....|..|: ..||   ::..:.|  |||   ||..|.......|:..||..||..|..
Human   268 CDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVHTGEKPFPCPF 332

  Fly   366 --CGRFYRTTSSLAVHKRTHAEKKPYNC--DQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAY 426
              ||:.:..:.:|.:|||||..:||:.|  :.|.|.:|.....::|...||.::||.|.:|||:|
Human   333 PGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSY 397

  Fly   427 YDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYK 461
            ...||||:|...|..:.:.:..      :..|||:
Human   398 THPSSLRKHMKVHESQGSDSSP------AASSGYE 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	49/153 (32%)
		C2H2 Zn finger	307..327	CDD:275368	4/17 (24%)
		C2H2 Zn finger	335..355	CDD:275368	8/24 (33%)
		C2H2 Zn finger	363..383	CDD:275368	7/21 (33%)
		COG5048	<387..523	CDD:227381	25/77 (32%)
		C2H2 Zn finger	391..411	CDD:275368	5/21 (24%)
		zf-H2C2_2	403..426	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	3/15 (20%)
		C2H2 Zn finger	475..495	CDD:275368
		zf-H2C2_2	487..510	CDD:290200
		C2H2 Zn finger	503..523	CDD:275368
ZIC3	NP_003404.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..107
		Nuclear localization signal	297..322		8/24 (33%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		SFP1	<324..408	CDD:227516	32/83 (39%)
		C2H2 Zn finger	330..352	CDD:275368	7/21 (33%)
		Nuclear localization signal	330..352		7/21 (33%)
		C2H2 Zn finger	360..382	CDD:275368	5/21 (24%)
		C2H2 Zn finger	390..410	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..467		6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910