DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and znf160

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001039100.1	Gene:	znf160 / 733919	XenbaseID:	XB-GENE-5962462	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	611	Identity:	148/611 - (24%)
Similarity:	253/611 - (41%)	Gaps:	108/611 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MNSKIAEVVVLN------CRTCTRACKLHKPLQEEIDLGSEGSTTLASMLNYCTGLSFEPQDGAA 60
            ||.|.....:.|      |......|.:.|...||:      .:..::..|.....|...||...
Frog     1 MNKKQITEKIFNHALEIICLLTGEECMVVKRNNEEV------HSIFSNAPNPIVEQSIHSQDRND 59

  Fly    61 MP-----QHICLHC--LQLL------------EQAFNFKRMVIDSD--------------ELLRL 92
            .|     :.:.|.|  :|||            |:..|:.|.||..:              |.|::
Frog    60 NPLLIREKILELGCKIIQLLTGELFLKEWKYFEEHRNYYRDVITENHQPLNSMGYSNVTPENLQI 124

  Fly    93 GLDEARC--------SSFHE--SQTH-SPNQSQQHDQQQQA----FDSTEEYVMIEMLNEEQENV 142
            ..:|:..        :..||  ||.| :.|.:.:.|.:|:.    .||.:..|:.:..::...||
Frog   125 KQEESSLLKKFKDSQNEIHEVSSQAHLNVNPADELDIKQEGENMMGDSRDCVVIPDDTDQAYLNV 189

  Fly   143 ANLDE-ELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQS---GDQQEEHI------- 196
            ...|: ::.:|...:  |....:...:.::.|||.::.|.:.|:|.|   |...|:..
Frog   190 NPADDLDIKQEGENM--MGESRDCVVIPDDTDQDSDVKEVDGQVAVSPVEGAWMEDDFRQCLYKE 252

  Fly   197 -TMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGE 260
             ::.|.......::......|..:.|:.|    :.:.|   ||..|        |||.| :::..
Frog   253 NSLPSRTSHGRCDIAQGIFANSIKNIIKE----QCLTD---HDTFL--------AEGDI-QIVQL 301

  Fly   261 ETLELEGDGR---------EEHLLPEAEDVCEDEDF---LEESLDSAP------PTAGEALPYVC 307
            ...|.|..|.         .:||..:..:..:..|:   .:....:.|      .||....|::|
Frog   302 NHGETEDSGSNSDHTNCLLNKHLNIDIHEASKKNDYYVNTDMGKRTTPCNLITSKTAKNEKPFIC 366

  Fly   308 TVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRT 372
            ..|.|.|.....|..||:.|..|:.|.|.||||......:...|..:||..:|..||.|.:.:..
Frog   367 LDCGKHFACNTHLTNHMKIHSGERPYSCNECGKSFTRNAHLGRHQASHTGERPFSCSECDKSFTR 431

  Fly   373 TSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKI 437
            :|.|.||:|:|:.:||:.|::||:.:.:...|.:|::.|.|:|||.|..|.|:|........|:.
Frog   432 SSYLIVHQRSHSGEKPFRCEECGKNFTSNTDLLKHQIIHKGDRPYVCGDCGKSYTHGYKFVIHQR 496

  Fly   438 SHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFK 502
            :|||::.|:|..||.....:|.:..|..:|:|...:.|:.||.::....:|..|.|.|:||:|:.
Frog   497 THTGERPFSCNECGKSFISRSNFAAHQKIHTGQGTYICNDCGKSYLSRFHLAIHQRTHTGERPYA 561

  Fly   503 CEVCVKAFPTKKRLASHMRVHNKESP 528
            |..|.|.|.::..|..|..:|..:.|
Frog   562 CSHCGKGFISRADLVRHEVIHRPQRP 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	21/109 (19%)
		COG5048	<297..451	CDD:227381	53/153 (35%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	44/135 (33%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		zf-H2C2_2	487..510	CDD:290200	10/22 (45%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
znf160	NP_001039100.1	COG5048	<306..517	CDD:227381	61/210 (29%)
		C2H2 Zn finger	366..386	CDD:275368	7/19 (37%)
		zf-H2C2_2	378..403	CDD:290200	11/24 (46%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		zf-H2C2_2	406..431	CDD:290200	7/24 (29%)
		C2H2 Zn finger	422..442	CDD:275368	8/19 (42%)
		zf-H2C2_2	434..459	CDD:290200	10/24 (42%)
		C2H2 Zn finger	450..470	CDD:275368	5/19 (26%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		zf-H2C2_2	494..515	CDD:290200	8/20 (40%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		C2H2 Zn finger	534..554	CDD:275368	6/19 (32%)
		zf-H2C2_2	546..571	CDD:290200	11/24 (46%)
		C2H2 Zn finger	562..582	CDD:275368	6/19 (32%)
		zf-H2C2_2	574..599	CDD:290200	4/14 (29%)
		zf-C2H2	588..610	CDD:278523	148/611 (24%)
		C2H2 Zn finger	590..610	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000