DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp619

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_036009324.1	Gene:	Zfp619 / 70227	MGIID:	1917477	Length:	1214	Species:	Mus musculus

Alignment Length:	226	Identity:	94/226 - (41%)
Similarity:	133/226 - (58%)	Gaps:	1/226 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 AGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQC 363
            |||. ||.|..|.|:|...|.|..|:|:|..||.|.|::|.|..:.|...:.|..:||..||::|
Mouse   574 AGEK-PYECKQCGKSFVYPCLLQVHVRTHTGEKPYRCKQCDKAFRSLSYLRIHEGSHTEEKPYEC 637

  Fly   364 SICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYD 428
            ..||:....:|:|.:|.|||..:|||.|.|||:.:..|.:||.|:.|||..:||.|..|.|....
Mouse   638 KECGKTLSCSSALQLHTRTHTGEKPYVCQQCGKAFRGFSYLRVHERTHTEAKPYECKQCGKILSC 702

  Fly   429 SSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVR 493
            ||||:.|:.:|||:|.::|..||......|..:.|.::|:|.|.|:|.:||.||.:.|.|..|.|
Mouse   703 SSSLQLHERTHTGEKPYSCNQCGKAFRGLSRLRVHEIIHTGEKPHECKLCGKAFRYRSLLRVHER 767

  Fly   494 LHSGEKPFKCEVCVKAFPTKKRLASHMRVHN 524
            .|:||||:.|:.|.|||.:...|..|.:.|:
Mouse   768 THTGEKPYACKQCSKAFKSLSNLRIHEKTHS 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	64/151 (42%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	58/135 (43%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
Zfp619	XP_036009324.1	KRAB	3..44	CDD:396083
		C2H2 Zn finger	245..265	CDD:275368
		C2H2 Zn finger	273..293	CDD:275368
		zf-H2C2_2	286..310	CDD:404364
		C2H2 Zn finger	301..321	CDD:275368
		C2H2 Zn finger	329..349	CDD:275368
		C2H2 Zn finger	357..377	CDD:275368
		COG5048	380..788	CDD:227381	91/214 (43%)
		C2H2 Zn finger	385..405	CDD:275368
		C2H2 Zn finger	413..433	CDD:275368
		C2H2 Zn finger	441..461	CDD:275368
		C2H2 Zn finger	469..489	CDD:275368
		C2H2 Zn finger	497..517	CDD:275368
		C2H2 Zn finger	525..545	CDD:275368
		C2H2 Zn finger	581..601	CDD:275368	8/19 (42%)
		C2H2 Zn finger	609..629	CDD:275368	5/19 (26%)
		C2H2 Zn finger	637..657	CDD:275368	7/19 (37%)
		C2H2 Zn finger	665..685	CDD:275368	8/19 (42%)
		C2H2 Zn finger	693..713	CDD:275368	8/19 (42%)
		C2H2 Zn finger	721..741	CDD:275368	5/19 (26%)
		COG5048	745..1142	CDD:227381	24/54 (44%)
		C2H2 Zn finger	749..769	CDD:275368	9/19 (47%)
		C2H2 Zn finger	777..797	CDD:275368	7/19 (37%)
		C2H2 Zn finger	803..823	CDD:275368
		C2H2 Zn finger	831..851	CDD:275368
		C2H2 Zn finger	859..879	CDD:275368
		C2H2 Zn finger	887..907	CDD:275368
		C2H2 Zn finger	915..935	CDD:275368
		C2H2 Zn finger	943..963	CDD:275368
		C2H2 Zn finger	997..1017	CDD:275368
		C2H2 Zn finger	1025..1045	CDD:275368
		C2H2 Zn finger	1053..1073	CDD:275368
		C2H2 Zn finger	1081..1101	CDD:275368
		C2H2 Zn finger	1109..1129	CDD:275368
		C2H2 Zn finger	1137..1157	CDD:275368
		C2H2 Zn finger	1165..1185	CDD:275368
		zf-H2C2_2	1178..1202	CDD:404364
		C2H2 Zn finger	1193..1213	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11471
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910