DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp449

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_003752124.1	Gene:	Zfp449 / 684901	RGDID:	1584453	Length:	518	Species:	Rattus norvegicus

Alignment Length:	387	Identity:	104/387 - (26%)
Similarity:	167/387 - (43%)	Gaps:	96/387 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 VDEEEEFLTEEVDQDDELSEEEHQLAQS------GDQQEEHIT----MESVHEFQPA-------- 207
            :|..||...::::...|:.    ||..|      |.:.||..:    :|:::.|...
  Rat   199 LDHREEPWVKDLEDPKEMK----QLLDSKIGFEMGIENEEDASKQKKLENLYPFVVTLEGNALHG 259

  Fly   208 ---EVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDG 269
               :.:||.::||:||              ...|...|...:|.|....:.|.
  Rat   260 PILQKDYVQLENEWET--------------SPEDLQTDLTKLVDPQNPTLGET------------ 298

  Fly   270 REEHLLPEAEDVCEDEDFLEESLDSAPP---TAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEK 331
                  ||..|       |||.|:..||   :.|:. |:.|..|.|.|.::.:|..|.|.|..|:
  Rat   299 ------PENPD-------LEEPLNPKPPKKKSPGDK-PHRCPQCGKCFARKSQLTGHQRIHSGEE 349

  Fly   332 QYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGR 396
            .::|.|||||.....:...|...||..:|::|::|.:.:...|.|..|:|||:|::.|.|.:||:
  Rat   350 PHKCPECGKRFLRSSDLYRHQRLHTGERPYECTVCKKRFTRRSHLLGHQRTHSEEETYKCLECGK 414

  Fly   397 GYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYK 461
            .:.....|:||..|||||:|:.|..|.|::...::|..|:.:||.::.|
  Rat   415 SFCHGSSLKRHLKTHTGEKPHRCHNCGKSFSRLTALTLHQRTHTEERPF---------------- 463

  Fly   462 KHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVH 523
                        ||..||.:|....:|..|:|:|:||||:||..|.|:|..:..|..|...|
  Rat   464 ------------KCSYCGKSFRQRPSLVIHLRIHTGEKPYKCTHCSKSFRQRAGLIMHQVTH 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	52/156 (33%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	41/135 (30%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	0/19 (0%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
Zfp449	XP_003752124.1	SCAN	27..134	CDD:413396
		COG5048	<323..483	CDD:227381	56/187 (30%)
		C2H2 Zn finger	325..345	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		zf-H2C2_2	477..502	CDD:404364	13/24 (54%)
		C2H2 Zn finger	493..513	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910