DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZSCAN5C

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001345342.1	Gene:	ZSCAN5C / 649137	HGNCID:	34294	Length:	496	Species:	Homo sapiens

Alignment Length:	518	Identity:	124/518 - (23%)
Similarity:	187/518 - (36%)	Gaps:	172/518 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AMPQHICLHCLQLLEQAFNFKRMVIDSDELLR-------------LGLD---------------E 96
            :|||.     ||:|.. .|..:...|.::|||             ||.:               .
Human    95 SMPQE-----LQVLVM-MNGVQSCKDLEDLLRNNRRPKKWSVVSFLGKEYLMQESDVEMAEAPAS 153

  Fly    97 ARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTV 161
            .|....|.|...:.:.:|...::.||....:....:..|...||....|.|..        .|..
Human   154 VRDDPRHVSSQRTSSVNQMCPEEGQASQELQTLPRVPALFRRQEEDFLLPETT--------VMKG 210

  Fly   162 DEE--------EEFLTEEVDQDDELSEEEHQL---------AQSGDQQEEHITMESVHEFQPAEV 209
            |.:        |:.|.|:.:::..|:..|.||         |:.|.:.::..::|:|....|:
Human   211 DPKALRPKPTLEKDLEEDREENPGLTSPEPQLPNSPTGVVGAKEGKEPQKRASVENVDADTPS-- 273

  Fly   210 EYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHL 274
                      ..|.|.   |....||:..                      :.|.|.|..|.:
Human   274 ----------ACVVER---EASTHSGSRG----------------------DALNLRGLKRSK-- 301

  Fly   275 LPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQ-HMR------SHVDEKQ 332
             |:|..:.::|            ..|||.|    |..:....|..:|. |..      ||
Human   302 -PDATSISQEE------------PQGEATP----VGNRESPGQAEINPVHSPGPAGPVSH----- 344

  Fly   333 YECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRG 397
                ..|:.:|.|             .|..|.:||:.::....||||.|:|..::.:.|:.||:.
Human   345 ----PSGQEVKEL-------------LPFACEVCGKRFKYRGKLAVHTRSHTGERLFQCNLCGKR 392

  Fly   398 YAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKK 462
            :.....|:.|:.||||||||.||:|.|.:...|.|:.||.||||:|.|.|:.|          ||
Human   393 FMQRIGLQFHQRTHTGERPYTCDICQKQFTQKSYLKCHKRSHTGEKPFECKDC----------KK 447

  Fly   463 HMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNK 525
                              .||:.:||..|.|:||||||.||..|.:||.....|..|.:.|.:
Human   448 ------------------VFTYKANLKEHQRIHSGEKPHKCSKCPRAFGRPATLRRHQKTHRE 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	9/30 (30%)
		COG5048	<297..451	CDD:227381	51/160 (32%)
		C2H2 Zn finger	307..327	CDD:275368	4/26 (15%)
		C2H2 Zn finger	335..355	CDD:275368	3/19 (16%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	50/135 (37%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	14/22 (64%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	4/19 (21%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		zf-H2C2_2	487..510	CDD:290200	13/22 (59%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
ZSCAN5C	NP_001345342.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		SCAN	40..124	CDD:153421	11/34 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..188		6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..347		37/216 (17%)
		zf-C2H2	356..378	CDD:333835	8/21 (38%)
		C2H2 Zn finger	358..378	CDD:275368	8/19 (42%)
		zf-H2C2_2	371..393	CDD:372612	9/21 (43%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		COG5048	410..>473	CDD:227381	35/90 (39%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		C2H2 Zn finger	442..462	CDD:275368	10/47 (21%)
		zf-C2H2	468..490	CDD:333835	7/21 (33%)
		C2H2 Zn finger	470..490	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910