DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and GZF1

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001303941.1	Gene:	GZF1 / 64412	HGNCID:	15808	Length:	711	Species:	Homo sapiens

Alignment Length:	558	Identity:	142/558 - (25%)
Similarity:	214/558 - (38%)	Gaps:	143/558 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LHCLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQ-----HDQQQQAFDST 126
            |.||.|.|..|..|:.:::| .||.|       .:|.|||....:...|     ..:...|.|..
Human   116 LKCLDLSETCFQLKKQMLES-VLLEL-------QNFSESQEVEVSSGSQVSAAPAPRASVATDGP 172

  Fly   127 EEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSE----------- 180
            ....:.:.|:...|..:|             .|:.|...:...:::|:..|:.:
Human   173 HPSGLTDSLDYPGERASN-------------GMSSDLPPKKSKDKLDKKKEVVKPPYPKIRRASG 224

  Fly   181 --------------------EEHQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNEFETIVTEE 225
                                .|.|....||..:.....:...:....|:|.|: |||
Human   225 RLAGRKVFVEIPKKKYTRRLREQQKTAEGDVGDYRCPQDQSPDRVGTEMEQVS-KNE-------- 280

  Fly   226 DEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLEL-EGDGREEHLLPEAED--------- 280
                            .||             .|.|..|| :..|.||....|.||
Human   281 ----------------GCQ-------------AGAELEELSKKAGPEEEEEEEEEDEEGEKKKSN 316

  Fly   281 ----VCEDEDFLEES-LDSAPPTAGEA--LPYVCTVCQKAFRQQCRLNQHMRS-HVDEKQYECEE 337
                :||.....|:| |..:....|.|  :.|.|..|.:.|..:|.|..|.|. |..|:.:.||.
Human   317 FKCSICEKAFLYEKSFLKHSKHRHGVATEVVYRCDTCGQTFANRCNLKSHQRHVHSSERHFPCEL 381

  Fly   338 CGKRLKHLRNYKEHML------------------------------THTNVKPHQCSICGRFYRT 372
            |||:.|..::.|.|:|                              |||..:|:.|:.||..:..
Human   382 CGKKFKRKKDVKRHVLQVHEGGGERHRCGQCGKGLSSKTALRLHERTHTGDRPYGCTECGARFSQ 446

  Fly   373 TSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKI 437
            .|:|..|.|.|..:||:.||:||..:.....|..||..||||||:.|:.|.|::.....|:.|..
Human   447 PSALKTHMRIHTGEKPFVCDECGARFTQNHMLIYHKRCHTGERPFMCETCGKSFASKEYLKHHNR 511

  Fly   438 SHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFK 502
            .|||.|.|.||:|....:|::...:|:.||:|.:.:.||.||..||..:.|..|.|:|:||:||.
Human   512 IHTGSKPFKCEVCFRTFAQRNSLYQHIKVHTGERPYCCDQCGKQFTQLNALQRHRRIHTGERPFM 576

  Fly   503 CEVCVKAFPTKKRLASHMRVHNKESPVTATVAVQSINP 540
            |..|.:.|..|..|..|..:|:|.:|..:.:.:...:|
Human   577 CNACGRTFTDKSTLRRHTSIHDKNTPWKSFLVIVDGSP 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	9/23 (39%)
		COG5048	<297..451	CDD:227381	60/186 (32%)
		C2H2 Zn finger	307..327	CDD:275368	7/20 (35%)
		C2H2 Zn finger	335..355	CDD:275368	9/49 (18%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	53/135 (39%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	10/22 (45%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
GZF1	NP_001303941.1	BTB	21..133	CDD:306997	7/16 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..220		10/79 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..312		22/106 (21%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		C2H2 Zn finger	350..371	CDD:275368	7/20 (35%)
		COG5048	<405..593	CDD:227381	64/187 (34%)
		C2H2 Zn finger	409..429	CDD:275368	0/19 (0%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..513	CDD:275368	5/19 (26%)
		C2H2 Zn finger	521..541	CDD:275368	5/19 (26%)
		C2H2 Zn finger	549..569	CDD:275368	9/19 (47%)
		C2H2 Zn finger	577..597	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100