DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and ZFP62

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001166109.1	Gene:	ZFP62 / 643836	HGNCID:	23241	Length:	900	Species:	Homo sapiens

Alignment Length:	520	Identity:	147/520 - (28%)
Similarity:	216/520 - (41%)	Gaps:	116/520 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 STEEYVMIEMLNEEQENVAN-------LDEELAEE---DRRIFAMTVDEEEEFLTEEVDQDDELS 179
            |||:    |...||.|||.|       :::.:.|.   |..::...|:.:::...|...::|:.|
Human     7 STED----EEPTEEYENVGNAASKWPKVEDPMPESKVGDTCVWDSKVENQQKKPVENRMKEDKSS 67

  Fly   180 EEE-----HQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNEFETIVTE---EDEFEVMNDSGA 236
            ..|     ...|....:||...:.:|:| ..|..:.:.|:.      :.:   |....|.|.:|.
Human    68 IREAISKAKSTANIKTEQEGEASEKSLH-LSPQHITHQTMP------IGQRGSEQGKRVENINGT 125

  Fly   237 HDAILDCQMIVIPAEGAIDEV-----------------IGEETLELE---GDGREEHLL------ 275
            ....|..:...:......||.                 .||:..|.:   |..|....|
Human   126 SYPSLQQKTNAVKKLHKCDECGKSFKYNSRLVQHKIMHTGEKRYECDDCGGTFRSSSSLRVHKRI 190

  Fly   276 -----PEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYEC 335
                 |...:.|........||.:...|........|..|.|:|.....|:||.|.|..||.|||
Human   191 HTGEKPYKCEECGKAYMSYSSLINHKSTHSGEKNCKCDECGKSFNYSSVLDQHKRIHTGEKPYEC 255

  Fly   336 EECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGY-- 398
            .||||..::....:.|...||..||::|.|||:.:..:|.|.||||.|..:|||.||:||:.:
Human   256 GECGKAFRNSSGLRVHKRIHTGEKPYECDICGKTFSNSSGLRVHKRIHTGEKPYECDECGKAFIT 320

  Fly   399 -----------------------AAFDH---LRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKI 437
                                   .:|::   |.:||:.||||:||.||.|.||:.:||.|..||.
Human   321 CRTLLNHKSIHFGDKPYKCDECEKSFNYSSLLIQHKVIHTGEKPYECDECGKAFRNSSGLIVHKR 385

  Fly   438 SHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHK---------------------------- 474
            .|||:|.:.|::||...|..||...|..:|.|.|||:
Human   386 IHTGEKPYKCDVCGKAFSYSSGLAVHKSIHPGKKAHECKECGKSFSYNSLLLQHRTIHTGERPYV 450

  Fly   475 CDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAVQSIN 539
            |||||..|...:.|..|.|||:||||:||:||.||:.::..|.:|..:|..|.|...:...:|.|
Human   451 CDVCGKTFRNNAGLKVHRRLHTGEKPYKCDVCGKAYISRSSLKNHKGIHLGEKPYKCSYCEKSFN 515

Fly 540 539
Human 516 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	67/181 (37%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	10/19 (53%)
		COG5048	<387..523	CDD:227381	66/191 (35%)
		C2H2 Zn finger	391..411	CDD:275368	8/47 (17%)
		zf-H2C2_2	403..426	CDD:290200	13/25 (52%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	14/22 (64%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
ZFP62	NP_001166109.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97		22/94 (23%)
		COG5048	125..552	CDD:227381	119/391 (30%)
		C2H2 Zn finger	143..163	CDD:275368	2/19 (11%)
		C2H2 Zn finger	171..191	CDD:275368	3/19 (16%)
		C2H2 Zn finger	199..219	CDD:275368	3/19 (16%)
		C2H2 Zn finger	227..247	CDD:275368	8/19 (42%)
		C2H2 Zn finger	255..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	283..303	CDD:275368	10/19 (53%)
		C2H2 Zn finger	311..331	CDD:275368	4/19 (21%)
		C2H2 Zn finger	339..359	CDD:275368	4/19 (21%)
		C2H2 Zn finger	367..387	CDD:275368	10/19 (53%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		C2H2 Zn finger	423..443	CDD:275368	0/19 (0%)
		COG5048	447..860	CDD:227381	28/69 (41%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		C2H2 Zn finger	507..527	CDD:275368	2/9 (22%)
		C2H2 Zn finger	535..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		C2H2 Zn finger	647..667	CDD:275368
		C2H2 Zn finger	675..695	CDD:275368
		C2H2 Zn finger	703..723	CDD:275368
		C2H2 Zn finger	731..751	CDD:275368
		C2H2 Zn finger	759..779	CDD:275368
		C2H2 Zn finger	787..807	CDD:275368
		C2H2 Zn finger	815..834	CDD:275368
		C2H2 Zn finger	842..862	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910