DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and SALL1

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_002959.2	Gene:	SALL1 / 6299	HGNCID:	10524	Length:	1324	Species:	Homo sapiens

Alignment Length:	574	Identity:	102/574 - (17%)
Similarity:	144/574 - (25%)	Gaps:	300/574 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 PAEGAIDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKA 313
            |..|.:|.....||.:|:.                    |.|::|.......|     |.:|.:.
Human   675 PFGGLLDSAQASETSKLQQ--------------------LVENIDKKATDPNE-----CIICHRV 714

  Fly   314 FRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKP----HQCSICGRFYRTTS 374
            ...|..|..|.|:|..|:.::|:.||:......|.|.|...|..:.|    |.|.||.:.:....
Human   715 LSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHYSVHRAMPPLRVQHSCPICQKKFTNAV 779

  Fly   375 SLAVHKRTHA------------------------EKKPY---------NCDQCGRG--------- 397
            .|..|.|.|.                        ::|.:         |.:.|..|
Human   780 VLQQHIRMHMGGQIPNTPVPDSYSESMESDTGSFDEKNFDDLDNFSDENMEDCPEGSIPDTPKSA 844

  Fly   398 ------------------YAAFDHLRR-------------------------------------- 406
                              .||.::..:
Human   845 DASQDSLSSSPLPLEMSSIAALENQMKMINAGLAEQLQASLKSVENGSIEGDVLTNDSSSVGGDM 909

  Fly   407 -----------------------------HKLTHTGERPY------------------------- 417
                                         ||.....|:|.
Human   910 ESQSAGSPAISESTSSMQALSPSNSTQEFHKSPSIEEKPQRAVPSEFANGLSPTPVNGGALDLTS 974

  Fly   418 ---------------------------ACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLS 455
                                       |||:|.|.:...|:|..|..|||.::.|.|.:|..|.|
Human   975 SHAEKIIKEDSLGILFPFRDRGKFKNTACDICGKTFACQSALDIHYRSHTKERPFICTVCNRGFS 1039

  Fly   456 QKSGYKKHMMVH----------------------------------------------------- 467
            .|...|:||:.|
Human  1040 TKGNLKQHMLTHQMRDLPSQLFEPSSNLGPNQNSAVIPANSLSSLIKTEVNGFVHVSPQDSKDTP 1104

  Fly   468 -----SG-------------------VKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVK 508
                 ||                   .|.|.|:.||..|:.:|.|..|.|.|:|||||.|.:|.:
Human  1105 TSHVPSGPLSSSATSPVLLPALPRRTPKQHYCNTCGKTFSSSSALQIHERTHTGEKPFACTICGR 1169

  Fly   509 AFPTKKRLASHMRVHNKESPVTATVAVQSINPPSRQAGAEGATGGGAT--GGSP 560
            ||.||..|..||..|...|            .|:|: |...:..|..|  ||:|
Human  1170 AFTTKGNLKVHMGTHMWNS------------TPARR-GRRLSVDGPMTFLGGNP 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	48/336 (14%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	58/367 (16%)
		C2H2 Zn finger	391..411	CDD:275368	6/113 (5%)
		zf-H2C2_2	403..426	CDD:290200	9/141 (6%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
SALL1	NP_002959.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..336
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..488	CDD:290200
		C2H2 Zn finger	479..499	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..646
		C2H2 Zn finger	708..728	CDD:275368	6/19 (32%)
		zf-H2C2_2	720..745	CDD:290200	8/24 (33%)
		C2H2 Zn finger	736..756	CDD:275368	6/19 (32%)
		zf-C2H2	766..788	CDD:278523	7/21 (33%)
		C2H2 Zn finger	768..788	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..856		4/65 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..963		4/68 (6%)
		C2H2 Zn finger	1003..1023	CDD:275370	7/19 (37%)
		zf-H2C2_2	1015..1040	CDD:290200	9/24 (38%)
		zf-C2H2	1029..1051	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1031..1051	CDD:275370	8/19 (42%)
		lambda-1	1064..>1155	CDD:212564	11/90 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1095..1120		2/24 (8%)
		zf-C2H2	1134..1156	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1136..1156	CDD:275368	8/19 (42%)
		zf-H2C2_2	1148..1173	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1164..1184	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910