DRSC/TRiP Functional Genomics Resources

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Protein Alignment dwg and ZNF462

DIOPT Version :9

Sequence 1:NP_477338.3 Gene:dwg / 31265 FlyBaseID:FBgn0000520 Length:592 Species:Drosophila melanogaster
Sequence 2:XP_006717272.1 Gene:ZNF462 / 58499 HGNCID:21684 Length:2567 Species:Homo sapiens


Alignment Length:601 Identity:117/601 - (19%)
Similarity:187/601 - (31%) Gaps:182/601 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 EQAFNFKRMVIDSD------------ELLRLGLDEARCSSFHESQTHS----------------P 110
            |:..||::..::.:            :..:|....|.....|.:..||                .
Human  1824 EERGNFEKAEVEGEAQEIEWLPFRCIKCFKLSFSTAELLCMHYTDHHSRDLKRDFIILGNGPRLQ 1888

  Fly   111 NQSQQHDQQQQAFDSTEEYVM-IEMLNEEQENVANLDE---ELAEEDRRIFAMTVDEEEEFLTEE 171
            |.:.|.........||.|... :.:.|||.:..|...|   :|..:.:.......|.::|.....
Human  1889 NSTYQCKHCDSKLQSTAELTSHLNIHNEEFQKRAKRQERRKQLLSKQKYADGAFADFKQERPFGH 1953

  Fly   172 VDQDDELSEEEHQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGA 236
            :::..::.|.:....:.....|.|.|:.::.......|:|..:......:..|.|:       .|
Human  1954 LEEVPKIKERKVVGYKCKFCVEVHPTLRAICNHLRKHVQYGNVPAVSAAVKQEADD-------PA 2011

  Fly   237 HDAILDCQMIVIPAEGA-IDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAG 300
            | ..||.......|.|| :..|.||..| |:|             :.|||        :.|  .|
Human  2012 H-LFLDGLEAAKDASGALVGRVDGEHCL-LDG-------------MLEDE--------TRP--GG 2051

  Fly   301 EALPYVCTVCQKAFRQQCRLNQHMRSHV------DEKQYECEECGKRLKHLRNYKEHMLT-HTNV 358
                |.|:.|.:.......|..|.|||:      .|.:|.|:.|........|...||.| |.:.
Human  2052 ----YHCSQCDRVLMSMQGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRHMQTHHGHH 2112

  Fly   359 KPHQCSICGRFYRTTSSLAVH-KRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGE-----RP- 416
            ||.:|.:|.......|.|..| .:.||.:..|.|..|.........|:.|.|...|:     || 
Human  2113 KPFRCKLCSFKSSYNSRLKTHILKAHAGEHAYKCSWCSFSTMTISQLKEHSLKVHGKALTLPRPR 2177

  Fly   417 -----------------------------YA---------------------------------- 418
                                         |:                                  
Human  2178 IVSLLSSHSHHSSQKATPAEEVEDSNDSSYSEPPDVQQQLNHYQSAALARNNSRVSPVPLSGAAA 2242

  Fly   419 -----------CDLCD-KAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMV-HS-- 468
                       |:.|: .:.|..|..|.::..|.|||.|.|:.|......||.:..|:.. ||  
Human  2243 GTEQKTEAVLHCEFCEFSSGYIQSIRRHYRDKHGGKKLFKCKDCSFYTGFKSAFTMHVEAGHSAV 2307

  Fly   469 ---GVKAHKCDVCGHAFTFTSNLNAHVRLHSGEK------------------PFKCEVCVKAFPT 512
               |.|..:|.:|.:...:..|:..|:.||..|:                  .|:|:.|.....:
Human  2308 PEEGPKDLRCPLCLYHTKYKRNMIDHIVLHREERVVPIEVCRSKLSKYLQGVVFRCDKCTFTCSS 2372

  Fly   513 KKRLASHMRVHNKESP 528
            .:.|..|:..||:..|
Human  2373 DESLQQHIEKHNELKP 2388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dwgNP_477338.3 zf-AD 14..91 CDD:214871 3/28 (11%)
COG5048 <297..451 CDD:227381 48/242 (20%)
C2H2 Zn finger 307..327 CDD:275368 5/19 (26%)
C2H2 Zn finger 335..355 CDD:275368 6/20 (30%)
C2H2 Zn finger 363..383 CDD:275368 5/20 (25%)
COG5048 <387..523 CDD:227381 41/240 (17%)
C2H2 Zn finger 391..411 CDD:275368 5/19 (26%)
zf-H2C2_2 403..426 CDD:290200 9/103 (9%)
C2H2 Zn finger 419..439 CDD:275368 5/20 (25%)
C2H2 Zn finger 447..467 CDD:275368 5/20 (25%)
C2H2 Zn finger 475..495 CDD:275368 4/19 (21%)
zf-H2C2_2 487..510 CDD:290200 8/40 (20%)
C2H2 Zn finger 503..523 CDD:275368 4/19 (21%)
ZNF462XP_006717272.1 C2H2 Zn finger 2054..2074 CDD:275368 5/19 (26%)
C2H2 Zn finger 2088..2108 CDD:275368 5/19 (26%)
C2H2 Zn finger 2117..2138 CDD:275368 5/20 (25%)
zf-H2C2_5 2144..2169 CDD:316431 6/24 (25%)
C2H2 Zn finger 2146..2167 CDD:275368 5/20 (25%)
C2H2 Zn finger 2317..2337 CDD:275368 4/19 (21%)
C2H2 Zn finger 2363..2383 CDD:275368 4/19 (21%)
C2H2 Zn finger 2391..2412 CDD:275368
C2H2 Zn finger 2477..2497 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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