DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF287

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001333096.1	Gene:	ZNF287 / 57336	HGNCID:	13502	Length:	761	Species:	Homo sapiens

Alignment Length:	606	Identity:	161/606 - (26%)
Similarity:	247/606 - (40%)	Gaps:	168/606 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 CLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQ------SQQHDQQQQAFDSTE 127
            ||:.|....:.|..::   |||.|          .:..|..|.:      ||..:..::|....|
Human    74 CLKWLRPEIHSKEQIL---ELLVL----------EQFLTILPGEVRTWVKSQYPESSEEAVTLVE 125

  Fly   128 EYVMIEMLNEEQENVANLDEELAEEDRR---------IFAMTVDEEEEFLTEEVDQDDELSEEEH 183
            :  :.::|.||....:.|.::..|||.|         :..:...|...|....||    :::|:.
Human   126 D--LTQILEEEAPQNSTLSQDTPEEDPRGKHAFQTGWLNDLVTKESMTFKDVAVD----ITQEDW 184

  Fly   184 QLAQSGDQQ-EEHITMES--------VHEFQPA-----EVEYVTIKN-------EFET------- 220
            :|.:...:: .:.:|:::        :..::|.     |..::.||.       |:||
Human   185 ELMRPVQKELYKTVTLQNYWNMVSLGLTVYRPTVIPILEEPWMVIKEILEGPSPEWETKAQACTP 249

  Fly   221 ------IVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEE-------TLELEGDGREE 272
                  :..||.....:.||..:|..|:.:     .:|...::..:|       .|..|.|..||
Human   250 VEDMSKLTKEETHTIKLEDSYDYDDRLERR-----GKGGFWKIHTDERGFSLKSVLSQEYDPTEE 309

  Fly   273 HLLPEAEDVCEDEDFLEES---------LDSAPPTAGEA--------------------LPYVCT 308
            .|  ...|:..: :|.:.|         ||:......|.                    .||.|.
Human   310 CL--SKYDIYRN-NFEKHSNLIVQFDTQLDNKTSVYNEGRATFNHVSYGIVHRKILPGEKPYKCN 371

  Fly   309 VCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTT 373
            ||.|.||:...|.:|..:|..||.||||||||..:|:.:...|...||..||::|..||:.:...
Human   372 VCGKKFRKYPSLLKHQSTHAKEKSYECEECGKEFRHISSLIAHQRMHTGEKPYECHQCGKAFSQR 436

  Fly   374 SSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKIS 438
            :.|.:|:|.|..:|||.||.||:.::...||..|:.|||||:||.|..|.|.:..||||..|:..
Human   437 AHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQRTHTGEKPYKCLECGKTFSHSSSLINHQRV 501

  Fly   439 HTGKKAFTCEICGVGLSQ-------------KSGYK---------------KHMMVHSGVKAHK- 474
            |||:|.:.|..||...||             |..||               :|..:|||.|.:|
Human   502 HTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKCYKC 566

  Fly   475 ---------------------------CDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPT 512
                                       |::||.||:.::||..|.|.|:||||:||.||.|||..
Human   567 NECGKAFAHSSTLIQHQTTHTGEKSYICNICGKAFSQSANLTQHHRTHTGEKPYKCSVCGKAFSQ 631

  Fly   513 KKRLASHMRVHNKESPVTATV 533
            ...|..|.|:||.|.|....:
Human   632 SVHLTQHQRIHNGEKPFKCNI 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	6/21 (29%)
		COG5048	<297..451	CDD:227381	65/173 (38%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	67/191 (35%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	13/22 (59%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	9/47 (19%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	14/22 (64%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
ZNF287	NP_001333096.1	SCAN	46..144	CDD:413396	18/84 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..154		6/19 (32%)
		KRAB	170..227	CDD:214630	8/60 (13%)
		SFP1	<364..419	CDD:227516	23/54 (43%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		COG5048	422..755	CDD:227381	80/231 (35%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	7/19 (37%)
		C2H2 Zn finger	482..502	CDD:275368	8/19 (42%)
		C2H2 Zn finger	510..530	CDD:275368	5/19 (26%)
		C2H2 Zn finger	538..558	CDD:275368	1/19 (5%)
		C2H2 Zn finger	566..586	CDD:275368	0/19 (0%)
		C2H2 Zn finger	594..614	CDD:275368	9/19 (47%)
		C2H2 Zn finger	622..642	CDD:275368	9/19 (47%)
		C2H2 Zn finger	650..670	CDD:275368	0/3 (0%)
		C2H2 Zn finger	678..698	CDD:275368
		C2H2 Zn finger	706..726	CDD:275368
		C2H2 Zn finger	734..754	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910