DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and BACH1

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001177.1	Gene:	BACH1 / 571	HGNCID:	935	Length:	736	Species:	Homo sapiens

Alignment Length:	246	Identity:	58/246 - (23%)
Similarity:	88/246 - (35%)	Gaps:	90/246 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 TIVTEEDEFEVMNDSGAHDAILDC------QMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEA 278
            ||..|...|.      ||.::|..      ..||..|:|.::..:.|| :.::|   .|.|:..|
Human    37 TIFVEGQRFR------AHRSVLAACSSYFHSRIVGQADGELNITLPEE-VTVKG---FEPLIQFA 91

  Fly   279 ------------EDVCEDEDFL-----EES---------LDSAPPTAGEALPYVCTVC--QKAFR 315
                        ::||:..:||     |||         |||   ||.:      ..|  :|.|.
Human    92 YTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFLDS---TADQ------QECPRKKCFS 147

  Fly   316 QQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFY---------- 370
            ..|:......|.:|::..|.:|.           |..|.:.||:..||.:  |.|
Human   148 SHCQKTDLKLSLLDQRDLETDEV-----------EEFLENKNVQTPQCKL--RRYQGNAKASPPL 199

  Fly   371 -----RTTSSLAVHKRTHAEKKPYNCDQCGRGYAAF--DHLRRHKLTHTGE 414
                 :|..|:.:.|.. |...|..|.:..:...||  |.:|      |||
Human   200 QDSASQTYESMCLEKDA-ALALPSLCPKYRKFQKAFGTDRVR------TGE 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	31/137 (23%)
		C2H2 Zn finger	307..327	CDD:275368	4/21 (19%)
		C2H2 Zn finger	335..355	CDD:275368	3/19 (16%)
		C2H2 Zn finger	363..383	CDD:275368	6/34 (18%)
		COG5048	<387..523	CDD:227381	9/30 (30%)
		C2H2 Zn finger	391..411	CDD:275368	5/21 (24%)
		zf-H2C2_2	403..426	CDD:290200	4/12 (33%)
		C2H2 Zn finger	419..439	CDD:275368
		C2H2 Zn finger	447..467	CDD:275368
		C2H2 Zn finger	475..495	CDD:275368
		zf-H2C2_2	487..510	CDD:290200
		C2H2 Zn finger	503..523	CDD:275368
BACH1	NP_001177.1	BTB	24..127	CDD:306997	24/99 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..312
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..389
		bZIP_BACH	551..621	CDD:269867
		coiled coil	555..617	CDD:269867
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	562..578
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	582..589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910