DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and si:dkey-208k4.2

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001093876.1	Gene:	si:dkey-208k4.2 / 570186	ZFINID:	ZDB-GENE-030131-6124	Length:	361	Species:	Danio rerio

Alignment Length:	268	Identity:	74/268 - (27%)
Similarity:	107/268 - (39%)	Gaps:	48/268 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 YEC--EECGKRLKHLRNYKEHMLTHTNVKPHQCSI--CGRFYRTTSSLAVHKRTHAEKKPYNCD- 392
            :.|  .|||.........:||...||.|:|::|.:  |||.:...|.|..|...|:..|.:.|:
Zfish    13 FNCVYAECGATFTRQWRLQEHETVHTGVRPYKCGVVGCGRSFTRKSHLNRHTSAHSGVKHFKCNI 77

  Fly   393 -QCGRGYAAFDHLRRH-KLTHT-GERPYAC--DLCDKAYYDSSSLRQHKISHTGKKAFTC--EIC 450
             .||:.:.|.|.|:|| :..|: .|..:.|  ..|.||:....:|:.|..:| |..:|.|  ..|
Zfish    78 TACGKKFQAADKLKRHVRYVHSENEEYFKCTEPQCSKAFRKRRALKLHLATH-GTSSFRCSKNNC 141

  Fly   451 GVGLSQKSGYKKHMMVHSGVKA--HKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTK 513
            |...........|...|.|.:.  .:|.:..|.:   .:|..|:..|  ...|.|.||.|||..:
Zfish   142 GKKFDSHIARNAHDRRHLGYRCLRTECPITVHTW---GSLIKHMASH--PVSFSCMVCKKAFRKR 201

  Fly   514 KRLASHMRVHNKESPVTATVAVQSINPPSRQAGAEGATGGGATGGSPTGGGATGGSATNL--HIT 576
            ..|..|.|.|..:.||...        ||:                  |..|...:..||  ||.
Zfish   202 DALRRHKRTHALQKPVLLC--------PSQ------------------GCQAYFSTTFNLQHHIR 240

  Fly   577 EVHEQPVS 584
            :||.|.:|
Zfish   241 KVHLQLLS 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	39/129 (30%)
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368	6/21 (29%)
		C2H2 Zn finger	363..383	CDD:275368	7/21 (33%)
		COG5048	<387..523	CDD:227381	41/145 (28%)
		C2H2 Zn finger	391..411	CDD:275368	8/22 (36%)
		zf-H2C2_2	403..426	CDD:290200	8/26 (31%)
		C2H2 Zn finger	419..439	CDD:275368	6/21 (29%)
		C2H2 Zn finger	447..467	CDD:275368	4/21 (19%)
		C2H2 Zn finger	475..495	CDD:275368	4/19 (21%)
		zf-H2C2_2	487..510	CDD:290200	8/22 (36%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
si:dkey-208k4.2	NP_001093876.1	COG5048	<18..168	CDD:227381	43/150 (29%)
		C2H2 Zn finger	19..37	CDD:275368	5/17 (29%)
		C2H2 Zn finger	45..67	CDD:275368	7/21 (33%)
		C2H2 Zn finger	75..95	CDD:275368	8/19 (42%)
		C2H2 Zn finger	110..129	CDD:275368	5/18 (28%)
		C2H2 Zn finger	136..158	CDD:275368	4/21 (19%)
		C2H2 Zn finger	166..185	CDD:275368	4/21 (19%)
		C2H2 Zn finger	191..211	CDD:275368	9/19 (47%)
		C2H2 Zn finger	220..240	CDD:275368	7/45 (16%)
		C2H2 Zn finger	251..270	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930