DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and znf652

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_005163894.1	Gene:	znf652 / 557571	ZFINID:	ZDB-GENE-030131-5857	Length:	648	Species:	Danio rerio

Alignment Length:	690	Identity:	160/690 - (23%)
Similarity:	252/690 - (36%)	Gaps:	186/690 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NCRTCTRACKLHKPLQEEIDLGSEGSTTLASMLNYCTGLSFEPQDGAAMPQHICLHCLQLLEQAF 77
            :|:|          |:||:. |.|..|              |.:.....|....:|.........
Zfish     3 SCQT----------LREELS-GLEAMT--------------EEERPMTQPSQTYIHNTSAPHSEL 42

  Fly    78 N---FKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQ----------------SQQHDQQQQAF 123
            :   :||...|:...|.:....|..|........:|||                |...:......
Zfish    43 SPKIYKREAEDTPYSLAIDSTMATDSQMPSELNPAPNQPFYREGAPAKTGNGGTSDDSEADDSGA 107

  Fly   124 DSTEEY----VMIEM-LNEEQENV-------------ANLDEELAEEDRRIFAMTVDEEEEFLTE 170
            .:.:|:    :::|: ||.:..:|             :|.:|:..|:|..      :||||...|
Zfish   108 GAEDEFKRGQIIVEVNLNNQTLHVSKGDDAGNAAGDKSNSEEDEDEDDEE------EEEEEDSVE 166

  Fly   171 E----VDQDDELSEEEH------QLAQSG------DQQEEHITMESV------------HEFQPA 207
            |    :|:|:|..||.:      |.||.|      .::...:...||            |...|.
Zfish   167 ENYSDLDEDEEEEEENNSRRTRAQRAQRGRTTAQPRRKSRRVAASSVTSSGVTTRGRRKHAEAPP 231

  Fly   208 EVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGREE 272
            :          :....:|.:....:.|||           .|..|.           .:|:|.|:
Zfish   232 Q----------KCRPAKEAKSSASSASGA-----------TPTGGG-----------AKGEGEEK 264

  Fly   273 HLLPEAEDVCE-------DEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDE 330
            ..|     .||       ...:||:.::     .......:|..|.|.|..:..|..|.::.. |
Zfish   265 ETL-----ACEKCPRVFNTRWYLEKHMN-----VTHRRMQICDKCGKKFVLESELALHQQTDC-E 318

  Fly   331 KQYECEECGKRLKHLRNYKEHM-LTHTNV-KPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQ 393
            |..:|..|.|..|.|.:..||: :.|... |...|.||.:.:.|.:.:..|...|.:..|:.|:.
Zfish   319 KNIQCVSCNKSFKKLWSLHEHIKIVHGFAEKKFACEICEKKFYTMAHVRKHMVAHTKDMPFTCET 383

  Fly   394 CGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKS 458
            ||:.:.....|:.|.|.|:||:|:.|:.||:.:.....||.|...|.|.|.|.|:.||...:.|.
Zfish   384 CGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQ 448

  Fly   459 GYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASH---- 519
            .:.:||..|:|.|...|::||.:||...|:..|.|.|:||||:.||:|.:.|.....|.:|
Zfish   449 YFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCEICGQRFRFSNMLKAHREKC 513

  Fly   520 MRVHNKES--PVTATV-------AVQSINPPSRQAGAEGATGGG-----ATGGSPTGGGATGGSA 570
            .||.:..|  |.|.|:       |..|.:.||....|:....|.     |..|.......|..|.
Zfish   514 FRVTSPVSLQPTTMTLPIHLTGHAPSSSHTPSPSQAAQPMPVGSVMISPAVSGPLPQRAVTAHSF 578

  Fly   571 TNLHI---------TEVHE-----------QPVSTSKVVM 590
            |:||:         |.||.           ||::....|:
Zfish   579 THLHMQTTPTHHSHTPVHHTGHAPMTSHAPQPITVQPSVL 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	14/79 (18%)
		COG5048	<297..451	CDD:227381	45/155 (29%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	7/20 (35%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		COG5048	<387..523	CDD:227381	50/139 (36%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	7/23 (30%)
znf652	XP_005163894.1	C2H2 Zn finger	269..288	CDD:275368	4/23 (17%)
		C2H2 Zn finger	296..315	CDD:275368	6/18 (33%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	5/19 (26%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	393..416	CDD:290200	10/22 (45%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		zf-H2C2_2	449..474	CDD:290200	9/24 (38%)
		C2H2 Zn finger	465..485	CDD:275368	8/19 (42%)
		zf-H2C2_2	477..500	CDD:290200	11/22 (50%)
		C2H2 Zn finger	493..510	CDD:275368	5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584080
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930