DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF692

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_011542525.1	Gene:	ZNF692 / 55657	HGNCID:	26049	Length:	625	Species:	Homo sapiens

Alignment Length:	289	Identity:	70/289 - (24%)
Similarity:	114/289 - (39%)	Gaps:	58/289 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 QPAEVEYVTIKN---------EFETIVTEEDE--FEVMNDSGAHDA--ILDCQMIVIPAEG---- 252
            :||.:.:.|.::         |...:.:|.||  .|....|...||  :|...:...|.||
Human   286 KPASLPHTTRRSWCSEATSGQELADLESEHDERTQEARLPSSEPDAPRLLPSPVTCTPKEGETPP 350

  Fly   253 ---AIDEVIGEETLELE---------GDGREEHLLPEAEDVCEDEDFLEES---LDSAPPTA--- 299
               |:...:....|...         .:.|.:..|.......:..:.|..:   ..|||..|
Human   351 APAALSSPLAVPALSASSLSSRAPPPAEVRVQPQLSRTPQAAQQTEALASTGSQAQSAPTPAWDE 415

  Fly   300 ---------------GEALPYVCTVCQKAFRQQCRLNQHMR-SHVDEKQYECEE--CGKRLKHLR 346
                           .|.:|.....|.:.|..:..||.|.: .|:.:|.:.|.|  |||.....:
Human   416 DTAQIGPKRIRKAAKRELMPCDFPGCGRIFSNRQYLNHHKKYQHIHQKSFSCPEPACGKSFNFKK 480

  Fly   347 NYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCG---RGYAAFD-HLRRH 407
            :.||||..|::.:.:.|..|.|.:||:|:|.:|:|.|..:||..|:.||   |..|:.: |.|:|
Human   481 HLKEHMKLHSDTRDYICEFCARSFRTSSNLVIHRRIHTGEKPLQCEICGFTCRQKASLNWHQRKH 545

  Fly   408 KLTHTGERPYACDLCDKAYYDSSSLRQHK 436
            ..|....| :.|:.|.|.:....|:..|:
Human   546 AETVAALR-FPCEFCGKRFEKPDSVAAHR 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	47/165 (28%)
		C2H2 Zn finger	307..327	CDD:275368	5/20 (25%)
		C2H2 Zn finger	335..355	CDD:275368	9/21 (43%)
		C2H2 Zn finger	363..383	CDD:275368	9/19 (47%)
		COG5048	<387..523	CDD:227381	17/54 (31%)
		C2H2 Zn finger	391..411	CDD:275368	8/23 (35%)
		zf-H2C2_2	403..426	CDD:290200	8/22 (36%)
		C2H2 Zn finger	419..439	CDD:275368	5/18 (28%)
		C2H2 Zn finger	447..467	CDD:275368
		C2H2 Zn finger	475..495	CDD:275368
		zf-H2C2_2	487..510	CDD:290200
		C2H2 Zn finger	503..523	CDD:275368
ZNF692	XP_011542525.1	zf-C2H2	465..489	CDD:278523	9/23 (39%)
		C2H2 Zn finger	467..489	CDD:275368	9/21 (43%)
		COG5048	490..>591	CDD:227381	27/85 (32%)
		zf-C2H2	495..517	CDD:278523	9/21 (43%)
		C2H2 Zn finger	497..517	CDD:275368	9/19 (47%)
		zf-H2C2_2	509..534	CDD:290200	9/24 (38%)
		C2H2 Zn finger	525..545	CDD:275368	7/19 (37%)
		C2H2 Zn finger	556..577	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910