DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and zbtb47a

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_683959.6	Gene:	zbtb47a / 556134	ZFINID:	ZDB-GENE-081104-121	Length:	671	Species:	Danio rerio

Alignment Length:	531	Identity:	133/531 - (25%)
Similarity:	213/531 - (40%)	Gaps:	155/531 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DLGSEGSTTLASMLNYCTGLSFEPQDGAAMPQHICLHCLQLLE-----------------QAFNF 79
            |:..|..||.|.:   |.|.|      ...|..:.:..||.::                 .:||.
Zfish   163 DIKQEKDTTCARI---CGGKS------EGNPYSVQVADLQSVQGGICKVEGKEPRNPEDPDSFNG 218

  Fly    80 KRMVID---SDELLRL--GLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQ 139
            ::::::   :::.|.:  |||.:       |...||: .||...::::.|.|.|        |.:
Zfish   219 EQIIVELNLNNQTLNVSKGLDGS-------SAAQSPS-GQQLSGKEKSSDGTFE--------ESR 267

  Fly   140 ENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMESVHEF 204
            .||                 |::||||      ::|.|.||:|        ..::.:.:|.
Zfish   268 NNV-----------------TLEEEEE------EEDGEQSEDE--------DDDDDVRLEG---- 297

  Fly   205 QPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETL-----E 264
                              |.|||.|         ::...:|    ...|...::.:.:.     |
Zfish   298 ------------------TSEDEGE---------SVFLSEM----KSRASAPLVSKRSCARARQE 331

  Fly   265 LEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMR-SHV 328
            .:.|..||.|         |:|..|.              :.|..|.|.|..:..|.:||. :|
Zfish   332 TDRDPSEERL---------DQDGFES--------------FSCLRCPKTFNNRWYLEKHMNVTH- 372

  Fly   329 DEKQYECEECGKRLKHLRNYKEHMLTHTNV---KPHQCSICGRFYRTTSSLAVHKRT---HAEKK 387
             .:...||:||||..    ....:|.|...   |..||..||:.:|...||..|.:.   :||||
Zfish   373 -NRMCVCEKCGKRFL----LDSELLLHQQTDCEKSIQCLTCGKAFRKLWSLHEHNKIVHGYAEKK 432

  Fly   388 PYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGV 452
             |.|:.|.:.:....|:|:|.:.||.|.|:.|:.|.|::..|.||:.|.:.|:|:|.|.||:|..
Zfish   433 -YTCEICEKKFYTMAHVRKHMVAHTKEMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFQCEVCSE 496

  Fly   453 GLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLA 517
            ....|...:.||.:|.|.|...|..||..|......:.|::.|:||||:.||:|.|:|.::..:.
Zfish   497 RFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPYICEICGKSFTSRPNMK 561

  Fly   518 SHMRVHNKESP 528
            .|.|.|..|.|
Zfish   562 RHRRTHTGEKP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	13/78 (17%)
		COG5048	<297..451	CDD:227381	52/160 (33%)
		C2H2 Zn finger	307..327	CDD:275368	7/20 (35%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/22 (32%)
		COG5048	<387..523	CDD:227381	48/135 (36%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		zf-H2C2_2	487..510	CDD:290200	10/22 (45%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
zbtb47a	XP_683959.6	BTB	32..137	CDD:279045
		BTB	46..141	CDD:197585
		C2H2 Zn finger	351..370	CDD:275368	7/18 (39%)
		C2H2 Zn finger	378..397	CDD:275368	8/22 (36%)
		C2H2 Zn finger	405..425	CDD:275368	7/19 (37%)
		C2H2 Zn finger	435..455	CDD:275368	5/19 (26%)
		zf-H2C2_2	447..472	CDD:290200	10/24 (42%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		zf-H2C2_2	475..498	CDD:290200	10/22 (45%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	519..539	CDD:275368	5/19 (26%)
		zf-H2C2_2	531..556	CDD:290200	11/24 (46%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-H2C2_2	559..582	CDD:290200	5/14 (36%)
		C2H2 Zn finger	575..592	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584086
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030