DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dwg and ZNF331

DIOPT Version :9

Sequence 1:NP_477338.3 Gene:dwg / 31265 FlyBaseID:FBgn0000520 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_001073375.1 Gene:ZNF331 / 55422 HGNCID:15489 Length:463 Species:Homo sapiens


Alignment Length:291 Identity:106/291 - (36%)
Similarity:150/291 - (51%) Gaps:18/291 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   304 PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGR 368
            ||.|..|:||||...:|.||.:.|..||.|||::|||..:...:...|...||..||::|..||:
Human   158 PYECKECKKAFRWGNQLTQHQKIHTGEKPYECKDCGKAFRWGSSLVIHKRIHTGEKPYECKDCGK 222

  Fly   369 FYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLR 433
            .:|....|..|:|.|..:|.|.|..||:.::....|.:||..|:||:||.|..|.||:...|||.
Human   223 AFRRGDELTQHQRFHTGEKDYECKDCGKTFSRVYKLIQHKRIHSGEKPYECKDCGKAFICGSSLI 287

  Fly   434 QHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGE 498
            |||..|||:|.:.|:.||...::.:...:|..:|:|.|.|:|..||.||.:.|:|..|.|:|:||
Human   288 QHKRIHTGEKPYECQECGKAFTRVNYLTQHQKIHTGEKPHECKECGKAFRWGSSLVKHERIHTGE 352

  Fly   499 KPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAVQSINPPSRQAGAEGATGGGA-------T 556
            ||:||..|.|||.....|..|.|:|..|:|...           ::.|.....|...       |
Human   353 KPYKCTECGKAFNCGYHLTQHERIHTGETPYKC-----------KECGKAFIYGSSLVKHERIHT 406

  Fly   557 GGSPTGGGATGGSATNLHITEVHEQPVSTSK 587
            |..|.|....|.|.::.|....|::..|.:|
Human   407 GVKPYGCTECGKSFSHGHQLTQHQKTHSGAK 437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dwgNP_477338.3 zf-AD 14..91 CDD:214871
COG5048 <297..451 CDD:227381 61/146 (42%)
C2H2 Zn finger 307..327 CDD:275368 9/19 (47%)
C2H2 Zn finger 335..355 CDD:275368 5/19 (26%)
C2H2 Zn finger 363..383 CDD:275368 7/19 (37%)
COG5048 <387..523 CDD:227381 58/135 (43%)
C2H2 Zn finger 391..411 CDD:275368 6/19 (32%)
zf-H2C2_2 403..426 CDD:290200 11/22 (50%)
C2H2 Zn finger 419..439 CDD:275368 10/19 (53%)
C2H2 Zn finger 447..467 CDD:275368 4/19 (21%)
C2H2 Zn finger 475..495 CDD:275368 9/19 (47%)
zf-H2C2_2 487..510 CDD:290200 12/22 (55%)
C2H2 Zn finger 503..523 CDD:275368 8/19 (42%)
ZNF331NP_001073375.1 KRAB 5..46 CDD:366587
COG5048 <32..284 CDD:227381 50/125 (40%)
C2H2 Zn finger 133..153 CDD:275368
C2H2 Zn finger 161..181 CDD:275368 9/19 (47%)
COG5048 185..441 CDD:227381 93/264 (35%)
C2H2 Zn finger 189..209 CDD:275368 5/19 (26%)
C2H2 Zn finger 217..237 CDD:275368 7/19 (37%)
C2H2 Zn finger 245..265 CDD:275368 6/19 (32%)
C2H2 Zn finger 273..293 CDD:275368 10/19 (53%)
C2H2 Zn finger 301..321 CDD:275368 4/19 (21%)
C2H2 Zn finger 329..349 CDD:275368 9/19 (47%)
C2H2 Zn finger 357..377 CDD:275368 8/19 (42%)
C2H2 Zn finger 385..405 CDD:275368 2/30 (7%)
C2H2 Zn finger 413..433 CDD:275368 4/19 (21%)
C2H2 Zn finger 441..461 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24384
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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