DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZSCAN2

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_024305746.1	Gene:	ZSCAN2 / 54993	HGNCID:	20994	Length:	645	Species:	Homo sapiens

Alignment Length:	532	Identity:	153/532 - (28%)
Similarity:	243/532 - (45%)	Gaps:	73/532 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 QQHDQQQQAFDS----TEEYVMIEMLNEE----------------QENVANLDE----ELAEEDR 154
            |:.|:|::...:    .:.:|...:|.|:                ||.|....:    .|.|..|
Human    21 QEEDRQEEEVTTMILEDDSWVQEAVLQEDGPESEPFPQSAGKGGPQEEVTRGPQGALGRLRELCR 85

  Fly   155 RIFAMTVDEEEEFLT---EEV-----DQDDELSEEEHQLAQSGDQQEEHITMESVHE-FQPAEVE 210
            |.....|..:|:.||   :|:     :...|.|||...|.:...|..:....:.||: |....|.
Human    86 RWLRPEVHTKEQMLTMLPKEIQAWLQEHRPESSEEAAALVEDLTQTLQDSGSQRVHQPFSVLTVC 150

  Fly   211 YVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIV-----------IPAEGAIDEVIGEETLE 264
            .|:.::....:....:.||:.:::|.     :|...:           :|...:.....||...|
Human   151 KVSSRSARRALELHLNYFEIQSENGE-----NCNQDMFENESRKIFSEMPEGESAQHSDGESDFE 210

  Fly   265 -------LEGDG-REEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLN 321
                   |:|.. .|:|    .|.|.:|.: :.:.:.......||. ||.|..|.|.|.::..|.
Human   211 RDAGIQRLQGHSPGEDH----GEVVSQDRE-VGQLIGLQGTYLGEK-PYECPQCGKTFSRKSHLI 269

  Fly   322 QHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEK 386
            .|.|:|..||.|:|:||||......|:..|..|||..||::|..||:.:..:::|..|:|.|..:
Human   270 THERTHTGEKYYKCDECGKSFSDGSNFSRHQTTHTGEKPYKCRDCGKSFSRSANLITHQRIHTGE 334

  Fly   387 KPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICG 451
            ||:.|.:||:.::...:|..|:.|||||:||:|..|.|::.:.|||..|:..|||:|.:.|:.||
Human   335 KPFQCAECGKSFSRSPNLIAHQRTHTGEKPYSCPECGKSFGNRSSLNTHQGIHTGEKPYECKECG 399

  Fly   452 VGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRL 516
            ...|..|...:|..:|:|.|.:||..||..|:.:|.|..|.|.|:||||::|..|.|:|.....|
Human   400 ESFSYNSNLIRHQRIHTGEKPYKCTDCGQRFSQSSALITHRRTHTGEKPYQCSECGKSFSRSSNL 464

  Fly   517 ASHMRVHNKESPVTATVAVQSINPPSRQAGAEGATGGGATGGSP----TGGGATGGSATNLHITE 577
            |:|.|.|..|.|....|..:|.:    |:.:..|..|..||..|    |.|.:...|:..|....
Human   465 ATHRRTHMVEKPYKCGVCGKSFS----QSSSLIAHQGMHTGEKPYECLTCGESFSWSSNLLKHQR 525

  Fly   578 VH--EQPVSTSK 587
            :|  |:|...|:
Human   526 IHTGEKPYKCSE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	60/153 (39%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	56/135 (41%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZSCAN2	XP_024305746.1	SCAN	70..157	CDD:322011	20/86 (23%)
		COG5048	251..631	CDD:227381	107/292 (37%)
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
		C2H2 Zn finger	283..303	CDD:275368	7/19 (37%)
		C2H2 Zn finger	311..331	CDD:275368	6/19 (32%)
		C2H2 Zn finger	339..359	CDD:275368	5/19 (26%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	479..499	CDD:275368	5/23 (22%)
		C2H2 Zn finger	507..527	CDD:275368	4/19 (21%)
		C2H2 Zn finger	535..555	CDD:275368	1/3 (33%)
		C2H2 Zn finger	563..583	CDD:275368
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870