DRSC/TRiP Functional Genomics Resources

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Protein Alignment dwg and MTF1

DIOPT Version :9

Sequence 1:NP_477338.3 Gene:dwg / 31265 FlyBaseID:FBgn0000520 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_005946.2 Gene:MTF1 / 4520 HGNCID:7428 Length:753 Species:Homo sapiens


Alignment Length:229 Identity:77/229 - (33%)
Similarity:111/229 - (48%) Gaps:36/229 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   332 QYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSI--CGRFYRTTSSLAVHKRTHAEKKPYNCDQ- 393
            |.||.|..::               .||.:||:.  |.|.|.|..:|..|::||..:..:.|:| 
Human   126 QSECPETKRK---------------EVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQE 175

  Fly   394 -CGRGYAAFDHLRRHKLTHTGERPYACDL--CDKAYYDSSSLRQHKISHTGKKAFTCEI--CGVG 453
             ||:.:.....||.|...||.|:|:.||:  |:||:.....|:.|:..||| |.|.||.  |...
Human   176 GCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTG-KTFNCESEGCSKY 239

  Fly   454 LSQKSGYKKHMMVHSGVKAHKC--DVCGHAFTFTSNLNAHVRLHSGEKPFKC--EVCVKAFPTKK 514
            .:..|..:||:..|:|.|..:|  |.||.||..:.:|..|||.|:||:||.|  ..|.|.|.|:.
Human   240 FTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQY 304

  Fly   515 RLASHMRVHNKESPVTATVAVQSINPPSRQAGAE 548
            .|.|||:.|:.:.        .|.|...:..|:|
Human   305 SLKSHMKGHDNKG--------HSYNALPQHNGSE 330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dwgNP_477338.3 zf-AD 14..91 CDD:214871
COG5048 <297..451 CDD:227381 41/126 (33%)
C2H2 Zn finger 307..327 CDD:275368
C2H2 Zn finger 335..355 CDD:275368 2/19 (11%)
C2H2 Zn finger 363..383 CDD:275368 7/21 (33%)
COG5048 <387..523 CDD:227381 56/145 (39%)
C2H2 Zn finger 391..411 CDD:275368 7/21 (33%)
zf-H2C2_2 403..426 CDD:290200 11/24 (46%)
C2H2 Zn finger 419..439 CDD:275368 7/21 (33%)
C2H2 Zn finger 447..467 CDD:275368 6/21 (29%)
C2H2 Zn finger 475..495 CDD:275368 10/21 (48%)
zf-H2C2_2 487..510 CDD:290200 12/24 (50%)
C2H2 Zn finger 503..523 CDD:275368 9/21 (43%)
MTF1NP_005946.2 COG5048 <93..291 CDD:227381 63/180 (35%)
Nuclear localization signal. /evidence=ECO:0000255 133..138 0/19 (0%)
C2H2 Zn finger 145..164 CDD:275368 6/18 (33%)
zf-H2C2_2 156..183 CDD:290200 8/26 (31%)
C2H2 Zn finger 172..194 CDD:275368 7/21 (33%)
zf-H2C2_2 186..213 CDD:290200 12/26 (46%)
C2H2 Zn finger 202..224 CDD:275368 7/21 (33%)
zf-C2H2_8 231..319 CDD:292531 34/95 (36%)
C2H2 Zn finger 234..253 CDD:275368 4/18 (22%)
zf-H2C2_2 245..271 CDD:290200 10/25 (40%)
C2H2 Zn finger 261..283 CDD:275368 10/21 (48%)
zf-H2C2_2 275..302 CDD:290200 13/26 (50%)
C2H2 Zn finger 291..313 CDD:275368 9/21 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 308..328 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 395..466
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 648..715
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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