DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and AgaP_AGAP012704

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_001230479.2	Gene:	AgaP_AGAP012704 / 4397589	VectorBaseID:	AGAP012704	Length:	285	Species:	Anopheles gambiae

Alignment Length:	377	Identity:	79/377 - (20%)
Similarity:	129/377 - (34%)	Gaps:	115/377 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ICLHCLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEY 129
            :||.|...|.::.:|:...|.::            .:||: ....|:.|..|...:...|.....
Mosquito     1 MCLECFDSLRRSADFRNACIRNE------------PTFHQ-MCIGPSTSDNHGLAKNTQDVDPLE 52

  Fly   130 VMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELS--EEEHQLAQSGDQQ 192
            |.||:|        .::.||.:||    ....|.|     :|...||:.:  |.|...|:.|.|
Mosquito    53 VQIEVL--------RVETELFDED----TQAPDSE-----KETPHDDDFTWHESETDPARDGKQ- 99

  Fly   193 EEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEV 257
                  :.|.:.:|                         |...|
Mosquito   100 ------KLVRKKRP-------------------------NRKRA--------------------- 112

  Fly   258 IGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQ 322
             |.|.::.....||.                     .:..|.|.:...:|::|....   ..||.
Mosquito   113 -GAEQIKRRDPAREA---------------------KSSSTGGRSTRVLCSICGTFV---SNLNF 152

  Fly   323 HMRSHVDEK--QYECEECGKRLKHLRNYKEHMLT-HTNVKPHQCSICGRFYRTTSSLAVHK-RTH 383
            |...|..:.  :..|..|..::.|.:|...|:.| |..:....|.|||:.:.|.:|...|. |.:
Mosquito   153 HQNYHHAKTSIKLSCPHCPAKITHQKNLTRHINTVHLKIVEKTCEICGKEFTTNNSYVSHMVRRY 217

  Fly   384 AEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQH 435
            ..:.||.|.||.:.:.:....:.|:|||:|.. :.|.||:|:|...|.|..|
Mosquito   218 IARWPYACTQCPKRFKSRFARKTHELTHSGVL-FKCTLCEKSYRYKSLLSMH 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	6/25 (24%)
		COG5048	<297..451	CDD:227381	41/143 (29%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	6/20 (30%)
		C2H2 Zn finger	363..383	CDD:275368	8/20 (40%)
		COG5048	<387..523	CDD:227381	18/49 (37%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	8/17 (47%)
		C2H2 Zn finger	447..467	CDD:275368
		C2H2 Zn finger	475..495	CDD:275368
		zf-H2C2_2	487..510	CDD:290200
		C2H2 Zn finger	503..523	CDD:275368
AgaP_AGAP012704	XP_001230479.2	C2H2 Zn finger	167..188	CDD:275368	6/20 (30%)
		C2H2 Zn finger	196..217	CDD:275368	8/20 (40%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		C2H2 Zn finger	252..270	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910