DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and CkIIalpha-i1

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_524096.2	Gene:	CkIIalpha-i1 / 39721	FlyBaseID:	FBgn0015025	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	74/403 - (18%)
Similarity:	133/403 - (33%)	Gaps:	127/403 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 QPAEVEYVTIKNEFETIVTEEDEFE----VMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLEL 265
            :|...|.:.|....|...|.:|||.    .::||.|....|:.             ...:|.:|.
  Fly    54 EPCFGETLRISESLEKWGTAQDEFHRRPIEIDDSTAFQIKLEV-------------TSNKEEVET 105

  Fly   266 EGDGRE----EHLL-PEAEDVCEDEDFLEESLDSAPPTAG-----------------------EA 302
            |.:..|    :|:. |..||..|..:.:|..::.:..||.                       :|
  Fly   106 EKNDEENSFDQHIAEPVKEDPLEKNEHMEIVVEESLKTASVDFFSVGLSRDGLAVTKFFKDKTQA 170

  Fly   303 LPYVCTVCQKAFRQQCRLNQHMRSHVDEKQ----YECEECGKRLKHLRNYKEHMLTHTNVKPHQC 363
            ...:||.|....    .:..|:|.|..:.:    |.|.:||.....|....|||.|    ..|..
  Fly   171 TRMLCTCCGHVL----EILTHIRMHSCKPRPNPVYYCRDCGSEFHKLHELHEHMKT----MKHNK 227

  Fly   364 SICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYD 428
            ::||                |:...:.|.:|.:.:..:..:.||:.:......:.|..|:.::.:
  Fly   228 TMCG----------------AKDLEFLCLRCNQIFPRYFDVIRHENSVHNVSDFICVECNMSFAN 276

  Fly   429 SSSLRQHKISH----TGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLN 489
            ..|.|:|..||    |.::.:.|.           ||.               |..::...:.|.
  Fly   277 QGSYRRHTRSHKVKFTQQRFYECP-----------YKD---------------CTSSYRVWARLM 315

  Fly   490 AHVRLHSGEKPFKCEV-------------------CVKAFPTKKRL-----ASHMRVHNKESPVT 530
            :|:..|.....||.:|                   ..:..|.:::|     :.:.:....|||..
  Fly   316 SHMSSHGLFSGFKSKVPSTQQERRLLEGKFMTLDPMKRVEPDRRKLPYRKKSFYAKADFPESPTK 380

  Fly   531 ATVAVQSINPPSR 543
            .|...:.|:.|.:
  Fly   381 CTNGGEFISLPKK 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	35/184 (19%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	2/19 (11%)
		COG5048	<387..523	CDD:227381	24/163 (15%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		zf-H2C2_2	403..426	CDD:290200	4/22 (18%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	3/19 (16%)
		C2H2 Zn finger	475..495	CDD:275368	3/19 (16%)
		zf-H2C2_2	487..510	CDD:290200	6/41 (15%)
		C2H2 Zn finger	503..523	CDD:275368	3/43 (7%)
CkIIalpha-i1	NP_524096.2	C2H2 Zn finger	175..191	CDD:275368	5/19 (26%)
		C2H2 Zn finger	203..225	CDD:275368	8/25 (32%)
		C2H2 Zn finger	239..259	CDD:275368	4/19 (21%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	299..321	CDD:275368	6/47 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100