DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF568

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	531	Identity:	146/531 - (27%)
Similarity:	226/531 - (42%)	Gaps:	124/531 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 EARCS-----SFHESQTHSPNQS------------QQHDQQQQAFDSTEEYVMIEMLNEEQENVA 143
            :|.||     |..|..|..|.::            ::.:|.:.|..:....||:    |...|:.
Human    25 KAWCSQESALSEEEEDTTRPLETVTFKDVAVDLTQEEWEQMKPAQRNLYRDVML----ENYSNLV 85

  Fly   144 NLDEELAEEDRRIFAMTVDEEEEFLTEEV---------DQDDELSEEEHQLAQSGDQ-------Q 192
            .:..::.:.| .||.:..:||...:.||:         :.|:::.:::..|.:....       :
Human    86 TVGCQVTKPD-VIFKLEQEEEPWVMEEEMFGRHCPEVWEVDEQIKKQQETLVRKVTSISKKILIK 149

  Fly   193 EEHITMESVHEFQPAEVEYVTIK--------------------------------NEF------- 218
            |:.|..:.|.:..|...:.||.:                                |||
Human   150 EKVIECKKVAKIFPLSSDIVTSRQSFYDCDSLDKGLEHNLDLLRYEKGCVREKQSNEFGKPFYHC 214

  Fly   219 -ETIVTE----------EDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDG--- 269
             ..:||.          ..:|:::.....|                    .||:..|.:..|
Human   215 ASYVVTPFKCNQCGQDFSHKFDLIRHERIH--------------------AGEKPYECKECGKAF 259

  Fly   270 -REEHLLP-------EAEDVCED--EDFLEES--LDSAPPTAGEALPYVCTVCQKAFRQQCRLNQ 322
             |:|:|:.       |....|.:  :.|::.|  :.......||. ||.|..|.|||.|:..|.:
Human   260 SRKENLITHQKIHTGEKPYKCNECGKAFIQMSNLIRHHRIHTGEK-PYACKDCWKAFSQKSNLIE 323

  Fly   323 HMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKK 387
            |.|.|..||.|||:||||.....:|..||...||..||:.|:.|||.:...||:.:|.|:|..:|
Human   324 HERIHTGEKPYECKECGKSFSQKQNLIEHEKIHTGEKPYACNECGRAFSRMSSVTLHMRSHTGEK 388

  Fly   388 PYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGV 452
            ||.|::||:.::.......|..:||||:||.|..|.||:..||||..|..:||.:|.:.|:.||.
Human   389 PYKCNKCGKAFSQCSVFIIHMRSHTGEKPYVCSECGKAFSQSSSLTVHMRNHTAEKPYECKECGK 453

  Fly   453 GLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLA 517
            ..|:|.....|..:|:|.|.::|..||.||...|||..|.|:|:||||:.|.||.|||..|..|.
Human   454 AFSRKENLITHQKIHTGEKPYECSECGKAFIQMSNLIRHQRIHTGEKPYACTVCGKAFSQKSNLT 518

  Fly   518 SHMRVHNKESP 528
            .|.::|..|.|
Human   519 EHEKIHTGEKP 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	65/153 (42%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	58/135 (43%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		zf-H2C2_2	487..510	CDD:290200	13/22 (59%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630	9/58 (16%)
		KRAB	48..87	CDD:279668	6/42 (14%)
		C2H2 Zn finger	224..244	CDD:275368	1/19 (5%)
		zf-H2C2_2	236..261	CDD:290200	5/44 (11%)
		COG5048	248..634	CDD:227381	109/283 (39%)
		C2H2 Zn finger	252..272	CDD:275368	4/19 (21%)
		zf-H2C2_2	264..289	CDD:290200	4/24 (17%)
		C2H2 Zn finger	280..300	CDD:275368	3/19 (16%)
		zf-H2C2_2	292..317	CDD:290200	9/25 (36%)
		C2H2 Zn finger	308..328	CDD:275368	9/19 (47%)
		zf-H2C2_2	320..345	CDD:290200	13/24 (54%)
		C2H2 Zn finger	336..356	CDD:275368	8/19 (42%)
		zf-H2C2_2	348..373	CDD:290200	11/24 (46%)
		C2H2 Zn finger	364..384	CDD:275368	8/19 (42%)
		zf-H2C2_2	380..401	CDD:290200	9/20 (45%)
		C2H2 Zn finger	392..412	CDD:275368	4/19 (21%)
		zf-H2C2_2	408..429	CDD:290200	11/20 (55%)
		C2H2 Zn finger	420..440	CDD:275368	9/19 (47%)
		zf-H2C2_2	432..457	CDD:290200	9/24 (38%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		zf-H2C2_2	460..485	CDD:290200	9/24 (38%)
		C2H2 Zn finger	476..496	CDD:275368	10/19 (53%)
		zf-H2C2_2	488..513	CDD:290200	15/24 (63%)
		C2H2 Zn finger	504..524	CDD:275368	9/19 (47%)
		zf-H2C2_2	516..541	CDD:290200	5/14 (36%)
		C2H2 Zn finger	532..552	CDD:275368
		zf-H2C2_2	544..569	CDD:290200
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	572..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	601..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910