DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp26

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001102465.2	Gene:	Zfp26 / 367033	RGDID:	1565847	Length:	956	Species:	Rattus norvegicus

Alignment Length:	650	Identity:	170/650 - (26%)
Similarity:	263/650 - (40%)	Gaps:	160/650 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EVVVLNCRTC---TRACKLHKPLQEEIDLGSEGSTTLASMLNYCTGL--------------SFEP 55
            ::..|:|.:.   .:.|.     |||   .:||.:||....:....:              |..|
  Rat     2 DITSLSCESLFSDDQICS-----QEE---ETEGESTLGEDCDKDEAVDCAQEEWTLKDPTQSSRP 58

  Fly    56 QDGAAMPQHICLHCLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQ-- 118
            .| .|:..|..|...: ||:....|....:.|.|.|                |:..::||.|.
  Rat    59 GD-VAVEDHTNLATAE-LEKQLQTKDSAPEQDFLAR----------------HTFMETQQVDAVT 105

  Fly   119 -QQQAFDST-EEYVMI---------EMLNEEQENVANLDEELAEE------DRRIFAMTVDEEEE 166
             :..|.|.| ||:..:         |::.|..:|:|.:..:|.:.      :|:: .:|| .|:.
  Rat   106 FEDVAVDFTQEEWTSLDPIQRTLYREVMLENYQNLATVGGQLFKPSLISWLERKV-ELTV-MEQG 168

  Fly   167 FLTE----------EVDQDDELSEEEH--QLAQ--SGDQQEEHITMESVHEFQPAEVEYVTIKNE 217
            .|.|          .:.||...|:..:  ||.:  ||.:..:.|.:.:|.........|::..:.
  Rat   169 ILQEWEMHLKTKRTALQQDRFWSDMSNGMQLGRELSGGELGDSIQVGTVFSEDSCPQTYISTPST 233

  Fly   218 FETIVTE---EDEFEVMNDSGAHDAILDCQMIVIPAEGAID----EVIGEETLELEGDGREEHLL 275
            .:|....   :|....:.::...:.||.....|.|.....|    ....|:::|....|:.  .:
  Rat   234 EDTSACHLRGKDFLPPLKETSTEENILQLNQCVKPLTLTPDVSQRMCTLEKSVECSDCGKT--FV 296

  Fly   276 PEAEDVCEDEDFLEESLDSAPPTAGEAL------------------------------------- 303
            .|.|.........|.:|.. |...|:|.
  Rat   297 NELELQAHSSSHSENNLHK-PEECGQAFTHPVSHDGHVIPTEKKYYECKKCEKFFTHPVYLNIHV 360

  Fly   304 -------PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGK------RL-KHLRNY------ 348
                   ||.|..|.|||.::..|..|:|.|..||.|||:||||      || :|:|::
  Rat   361 QSHTVEKPYDCKECGKAFTERSSLIVHLRQHTREKSYECKECGKTFIQPSRLTEHMRSHTGEKPY 425

  Fly   349 ---------------KEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGY 398
                           ..|:.|||..||.:|:|||:.:..:|.|..|.|||..:|||.|..||:.:
  Rat   426 QCDQCGNAFASSSYLTTHLRTHTGEKPFECNICGKAFTRSSYLLGHIRTHTGEKPYECKVCGKAF 490

  Fly   399 AAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKH 463
            :....|..|...|||||||.|..|:||:...:.|.:|..:|||:|.|.|::|.......|..|.|
  Rat   491 SGRSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTHTGEKPFRCKVCARTFRNSSCLKTH 555

  Fly   464 MMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            ..:|:|:|.:||:.||..||..|.|..||.:|:||||::|:.|.|||.|...|..|:|:|..|.|
  Rat   556 FRIHTGIKPYKCNYCGKDFTARSGLTKHVLIHNGEKPYECKECGKAFSTSSGLVEHIRIHTGEKP 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	20/93 (22%)
		COG5048	<297..451	CDD:227381	69/225 (31%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	10/47 (21%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	58/135 (43%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
Zfp26	NP_001102465.2	KRAB	104..162	CDD:214630	11/58 (19%)
		C2H2 Zn finger	288..308	CDD:275368	3/21 (14%)
		COG5048	338..751	CDD:227381	100/282 (35%)
		C2H2 Zn finger	343..363	CDD:275368	0/19 (0%)
		C2H2 Zn finger	371..391	CDD:275368	8/19 (42%)
		C2H2 Zn finger	399..419	CDD:275368	9/19 (47%)
		C2H2 Zn finger	427..447	CDD:275368	1/19 (5%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
		C2H2 Zn finger	483..503	CDD:275368	5/19 (26%)
		C2H2 Zn finger	511..531	CDD:275368	6/19 (32%)
		C2H2 Zn finger	539..559	CDD:275368	5/19 (26%)
		C2H2 Zn finger	567..587	CDD:275368	9/19 (47%)
		COG5048	591..>918	CDD:227381	13/29 (45%)
		C2H2 Zn finger	595..615	CDD:275368	9/19 (47%)
		C2H2 Zn finger	623..643	CDD:275368
		C2H2 Zn finger	651..671	CDD:275368
		C2H2 Zn finger	679..699	CDD:275368
		C2H2 Zn finger	707..727	CDD:275368
		C2H2 Zn finger	735..755	CDD:275368
		C2H2 Zn finger	763..783	CDD:275368
		C2H2 Zn finger	791..811	CDD:275368
		C2H2 Zn finger	819..839	CDD:275368
		C2H2 Zn finger	847..867	CDD:275368
		C2H2 Zn finger	875..895	CDD:275368
		C2H2 Zn finger	903..923	CDD:275368
		C2H2 Zn finger	931..947	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910