DRSC/TRiP Functional Genomics Resources

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Protein Alignment dwg and ZSCAN22

DIOPT Version :9

Sequence 1:NP_477338.3 Gene:dwg / 31265 FlyBaseID:FBgn0000520 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_001308045.1 Gene:ZSCAN22 / 342945 HGNCID:4929 Length:491 Species:Homo sapiens


Alignment Length:478 Identity:132/478 - (27%)
Similarity:200/478 - (41%) Gaps:122/478 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 EEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMESV----------------HE-------- 203
            ||:.||..:|::     |||..|:|.|:...:||.....                ||        
Human    14 EEDSFLQVKVEE-----EEEASLSQGGESSHDHIAHSEAARLRFRHFRYEEASGPHEALAHLRAL 73

  Fly   204 ----FQP-----AEVEYVTIKNEF---------------------ETIVTEEDEFEVMN----DS 234
                .||     .::..:.:..:|                     |..|..||..:|::    |.
Human    74 CCQWLQPEAHSKEQILELLVLEQFLGALPPEIQAWVGAQSPKSGEEAAVLVEDLTQVLDKRGWDP 138

  Fly   235 GAHDAILDCQMIVI-------------------PA-------EGAIDE--VIGE----------- 260
            ||......|:...:                   ||       ||:.:.  :.||           
Human   139 GAEPTEASCKQSDLGESEPSNVTETLMGGVSLGPAFVKACEPEGSSERSGLSGEIWTKSVTQQIH 203

  Fly   261 --------ETLELEGDGREE-----------HLLPEAEDVCEDEDFLEESLDSAPP-TAGEALPY 305
                    :.:..:..|||.           :|..:.:...||:..|.::..:.|| |.......
Human   204 FKKTSGPYKDVPTDQRGRESGASRNSSSAWPNLTSQEKPPSEDKFDLVDAYGTEPPYTYSGKRSS 268

  Fly   306 VCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFY 370
            .|..|:|.|:....|..|.::|..:..|.|.||||......:..:|.:.||..|||:|..||:.:
Human   269 KCRECRKMFQSASALEAHQKTHSRKTPYACSECGKAFSRSTHLAQHQVVHTGAKPHECKECGKAF 333

  Fly   371 RTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQH 435
            ...:.|..|:|.|..:|||.|.:||:.::...||.:|:..|||||||.||.|.||:..|:.|.||
Human   334 SRVTHLTQHQRIHTGEKPYKCGECGKTFSRSTHLTQHQRVHTGERPYECDACGKAFSQSTHLTQH 398

  Fly   436 KISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKP 500
            :..|||:|.:.|:.||...|..|...:|:.:|||.|.::|.||..||..:|:|..|.|:|:||||
Human   399 QRIHTGEKPYKCDACGRAFSDCSALIRHLRIHSGEKPYQCKVCPKAFAQSSSLIEHQRIHTGEKP 463

  Fly   501 FKCEVCVKAFPTKKRLASHMRVH 523
            :||..|.|||.....|..|:|:|
Human   464 YKCSDCGKAFSRSSALMVHLRIH 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dwgNP_477338.3 zf-AD 14..91 CDD:214871
COG5048 <297..451 CDD:227381 58/154 (38%)
C2H2 Zn finger 307..327 CDD:275368 6/19 (32%)
C2H2 Zn finger 335..355 CDD:275368 6/19 (32%)
C2H2 Zn finger 363..383 CDD:275368 6/19 (32%)
COG5048 <387..523 CDD:227381 62/135 (46%)
C2H2 Zn finger 391..411 CDD:275368 6/19 (32%)
zf-H2C2_2 403..426 CDD:290200 14/22 (64%)
C2H2 Zn finger 419..439 CDD:275368 9/19 (47%)
C2H2 Zn finger 447..467 CDD:275368 6/19 (32%)
C2H2 Zn finger 475..495 CDD:275368 9/19 (47%)
zf-H2C2_2 487..510 CDD:290200 12/22 (55%)
C2H2 Zn finger 503..523 CDD:275368 8/19 (42%)
ZSCAN22NP_001308045.1 SCAN 45..133 CDD:307924 10/87 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 134..161 4/26 (15%)
COG5048 <174..482 CDD:227381 100/307 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..249 6/44 (14%)
C2H2 Zn finger 270..290 CDD:275368 6/19 (32%)
C2H2 Zn finger 298..318 CDD:275368 6/19 (32%)
C2H2 Zn finger 326..346 CDD:275368 6/19 (32%)
C2H2 Zn finger 354..374 CDD:275368 6/19 (32%)
C2H2 Zn finger 382..402 CDD:275368 9/19 (47%)
C2H2 Zn finger 410..430 CDD:275368 6/19 (32%)
C2H2 Zn finger 438..458 CDD:275368 9/19 (47%)
C2H2 Zn finger 466..486 CDD:275368 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
21.870

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