DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp513

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001012110.1	Gene:	Zfp513 / 313913	RGDID:	1310456	Length:	541	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	127/554 - (22%)
Similarity:	183/554 - (33%)	Gaps:	196/554 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 VDEEEEF------LTEEVD----QDDELSEEEHQLAQSGDQQEEHI---TMESVHEFQPAE--VE 210
            ||.|:.|      |..|.|    ||.|..|||.:  :.||...:.:   ..:|..:.|.|.  :.
  Rat    19 VDTEDSFDEGPGALVLESDLLLGQDLEFEEEEEE--EEGDGHNDQLMGFERDSEGDSQGARPGLP 81

  Fly   211 YVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHLL 275
            |          ...:||      ||...|:.....:..||.|.     ||...|..|...:....
  Rat    82 Y----------GLSDDE------SGGGRALSAESEVEEPARGP-----GEARGERPGPACQLCGG 125

  Fly   276 PEAEDVCEDEDFLEESLDSAPPTAGEALP----YVCTVCQKAFRQQCRLNQHMRSHVDEKQYECE 336
            |..|..|         ..:..|..|..||    |.|.:|.........|.:||::|..||.:.|.
  Rat   126 PTGEGPC---------CGAGGPGGGPPLPPRLLYSCRLCAFVSHYSSHLKRHMQTHSGEKPFRCG 181

  Fly   337 ECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTH------------------ 383
            .|......|.|...|..|||..||::|..|.....:..:|..|:|||
  Rat   182 RCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHTGPPTPPCPTCGFRCCAP 246

  Fly   384 --------AEKK----------------------------------------------------- 387
                    .|::
  Rat   247 RPTRPPSPTEQEGTMPRRSEDALILPDLSLHVPPGGTSFLPDCGQLRGEGEGLCGTGSEPLPELL 311

  Fly   388 -PYNCDQCG-------------------------------------RGYAAF---------DHLR 405
             |:.|..||                                     :|:|..         :||.
  Rat   312 FPWTCRGCGQELEEGEGSRLGTAMCGRCMRGESGGGGSGGPQGPSDKGFACSLCPFATHYPNHLA 376

  Fly   406 RHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGV 470
            ||..||:||:|:.|..|..|.....:|::|:..|||:|.:.|.:|.......:..|:|..:|||.
  Rat   377 RHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHSGD 441

  Fly   471 KAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPT-----KKRLASHMRVHNKESPVT 530
            |..:|.:|.::...:.||..|:..|:|||||:|..|  |:.|     .||   |.:||.......
  Rat   442 KPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATC--AYTTGHWDNYKR---HQKVHGHGGAGG 501

  Fly   531 ATVAVQS-----INPPS----RQAGAEGATGGGA 555
            ..::...     .:|||    |.:.|.||||..|
  Rat   502 PGLSAPEGWAPPHSPPSVLSTRGSAALGATGSRA 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	56/283 (20%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		COG5048	<387..523	CDD:227381	50/240 (21%)
		C2H2 Zn finger	391..411	CDD:275368	9/65 (14%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	4/19 (21%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	7/24 (29%)
Zfp513	NP_001012110.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		31/123 (25%)
		C2H2 Zn finger	152..172	CDD:275368	5/19 (26%)
		zf-H2C2_2	164..189	CDD:290200	8/24 (33%)
		COG5048	176..>228	CDD:227381	16/51 (31%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		zf-H2C2_2	192..217	CDD:290200	9/24 (38%)
		C2H2 Zn finger	208..228	CDD:275368	5/19 (26%)
		C2H2 Zn finger	362..382	CDD:275368	4/19 (21%)
		COG5048	<372..>450	CDD:227381	27/77 (35%)
		zf-H2C2_2	374..399	CDD:290200	12/24 (50%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		zf-H2C2_2	402..425	CDD:290200	8/22 (36%)
		COG5048	414..>487	CDD:227381	24/74 (32%)
		C2H2 Zn finger	418..438	CDD:275368	4/19 (21%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		zf-H2C2_2	458..481	CDD:290200	12/24 (50%)
		C2H2 Zn finger	474..493	CDD:275368	7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..541		12/44 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343822
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930