DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and Gzf1

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001101258.1	Gene:	Gzf1 / 311508	RGDID:	1562321	Length:	707	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	139/553 - (25%)
Similarity:	216/553 - (39%)	Gaps:	134/553 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LHCLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQ--------------HD 117
            |.||.|.|.....|:.:::| .||.|       .:|.|||....:...|              .|
  Rat   116 LKCLDLSETCLQLKKQMLES-VLLEL-------QNFSESQEVEASSGPQVSVTPSSKASVPAGED 172

  Fly   118 QQQQAFDSTEEYVMIEMLN---------------EEQENVA--------NLDEELAEEDRRIFAM 159
            ........:.:|.:..:.|               :::::||        .....||  .:::|..
  Rat   173 AHSNGLVDSSDYPIERLGNGLSPETPSKKCKEKLDKKKDVAKPPFPKIRRASGRLA--GKKVFVE 235

  Fly   160 TVDE-------EEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNE 217
            ...:       |::...||..::|:..::     ||.|.:.......|..|..||.||
  Rat   236 IPKKKYTRRLREQQKSAEEAAKNDKCPQD-----QSPDNERVEAEPASKSEACPASVE------- 288

  Fly   218 FETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEAEDVC 282
                                            .|.::.:|.||:..|...||.|:........||
  Rat   289 --------------------------------REESLQKVEGEKEEEEGKDGEEKKKSNFQCTVC 321

  Fly   283 EDEDFLEES--LDSAPPTAGEA--LPYVCTVCQKAFRQQCRLNQHMRS-HVDEKQYECEECGKRL 342
             |:.||.|.  |.......|.|  :.|.|..|.:.|..:|.|..|.|. |..|:.:.||.|.|:.
  Rat   322 -DKAFLYEKSFLKHIKYHHGVATEVVYRCDTCGQTFANRCNLKSHQRHVHSSERHFPCEMCAKKF 385

  Fly   343 KHLRNYKEHML------------------------------THTNVKPHQCSICGRFYRTTSSLA 377
            |..::.|.|:|                              |||..||:.|:.|...:...|:|.
  Rat   386 KRKKDVKRHVLQVHEGGGERHRCGQCGKGLSSKTALRLHERTHTGDKPYGCTKCDAKFSQPSALK 450

  Fly   378 VHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGK 442
            .|.|.|..::|:.||:||..:.....|..||..||||||:.|:.|.|::.....|:.|...|||.
  Rat   451 THLRVHTGERPFVCDECGARFTQNHMLIYHKRCHTGERPFMCETCGKSFASKEYLKHHNRIHTGS 515

  Fly   443 KAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCV 507
            |.|.||:|....:|::...:|:.||:|.:.:.||.||..||..:.|..|.|:|:||||:.|..|.
  Rat   516 KPFKCEVCLRTFAQRNSLYQHIKVHTGERPYCCDQCGKQFTQVNALQRHHRIHTGEKPYMCNACG 580

  Fly   508 KAFPTKKRLASHMRVHNKESPVTATVAVQSINP 540
            :.|..|..|..|..:|:|.:|..:.:.:...:|
  Rat   581 RTFTDKSTLRRHTSIHDKNTPWKSFLVIVDGSP 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	8/23 (35%)
		COG5048	<297..451	CDD:227381	58/186 (31%)
		C2H2 Zn finger	307..327	CDD:275368	7/20 (35%)
		C2H2 Zn finger	335..355	CDD:275368	8/49 (16%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	52/135 (39%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	10/22 (45%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
Gzf1	NP_001101258.1	BTB	21..125	CDD:279045	5/8 (63%)
		BTB	32..125	CDD:197585	5/8 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..221		6/71 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..309		19/109 (17%)
		C2H2 Zn finger	318..338	CDD:275370	7/20 (35%)
		C2H2 Zn finger	349..370	CDD:275368	7/20 (35%)
		C2H2 Zn finger	408..428	CDD:275368	0/19 (0%)
		COG5048	<411..539	CDD:227381	41/127 (32%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		zf-H2C2_2	448..473	CDD:290200	9/24 (38%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		zf-H2C2_2	476..501	CDD:290200	12/24 (50%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		zf-H2C2_2	504..529	CDD:290200	10/24 (42%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		zf-H2C2_2	532..557	CDD:290200	9/24 (38%)
		COG5048	544..>601	CDD:227381	22/56 (39%)
		C2H2 Zn finger	548..568	CDD:275368	9/19 (47%)
		zf-H2C2_2	560..584	CDD:290200	10/23 (43%)
		C2H2 Zn finger	576..596	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100