DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp354c

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_038950.3	Gene:	Zfp354c / 30944	MGIID:	1353621	Length:	560	Species:	Mus musculus

Alignment Length:	483	Identity:	134/483 - (27%)
Similarity:	208/483 - (43%)	Gaps:	99/483 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 DSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQS 188
            |..:..:..|::.|...|:|:|..:.:...  :.......::..:..|..:|..|..|.....::
Mouse    32 DPAQRSLYREVMLENYSNLASLGFQASIPP--VIGKLQKGQDPCMEREAPEDTCLDFEIWPEIEA 94

  Fly   189 GDQQEEHITMESVHE-FQPAEVEYVTIKNEF-ETIVTE-----EDEFEVMNDSGAHDAILDCQMI 246
            ...:::.:|.|:.|. .:....:.|..|..| |.:.||     :::.:.::..||..
Mouse    95 LPPKQDVLTKETSHGLIKNGSTKCVYWKISFGELVKTECRDIAQEQEKKVHGPGAES-------- 151

  Fly   247 VIPAEGAIDE------------VIGEETLELEGDGREEHLLP-----EAEDVCEDEDFLEESLDS 294
              |.|...::            .|.:..:..|||..|.  :|     ..:|:.:|.| |..|...
Mouse   152 --PKETTSEDGTPTGFEPEKPLFISKALVSQEGDPTES--VPATYHTSEKDLPQDFD-LMRSFQM 211

  Fly   295 APPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVK 359
            .|   |:. |:||:.|.|.|.|...|.:|.|.|..||.|:|.||||...|..:...|..|||..|
Mouse   212 YP---GQK-PHVCSECGKGFTQSLHLLEHKRLHTGEKPYKCSECGKSFSHRSSLLAHQRTHTGEK 272

  Fly   360 PHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYA------------------------- 399
            |::||.|.:.:.::|:|..|.|.|..:|||.|.|||:.::
Mouse   273 PYKCSECEKAFGSSSTLIKHLRVHTGEKPYRCRQCGKAFSQCSTLTVHQRIHTGEKLYKCAECDK 337

  Fly   400 AFD---HLRRHKLTHTGERPYACDLCDKAYYDSSSLRQH--------------------KIS--- 438
            ||:   .|.||:..||||:||.|..|.|.|....||.:|                    ::|
Mouse   338 AFNCRAKLHRHQRIHTGEKPYKCAECGKGYSQFPSLAEHQRLHTGEQLCQCLQCGRTFTRVSTLI 402

  Fly   439 -----HTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGE 498
                 |||:|.:.|..||...:|.|.:.:|..:|:|.|.:.|:.||.||...|||..|.|:|:||
Mouse   403 EHQRIHTGQKPYQCNECGKTFNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRHQRIHTGE 467

  Fly   499 KPFKCEVCVKAFPTKKRLASHMRVHNKE 526
            ||::|..|.|||.....|..|.|:|..|
Mouse   468 KPYQCNQCGKAFSQYSFLTEHERIHTGE 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	66/209 (32%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	62/191 (32%)
		C2H2 Zn finger	391..411	CDD:275368	9/47 (19%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	8/47 (17%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
Zfp354c	NP_038950.3	KRAB	14..74	CDD:214630	6/43 (14%)
		KRAB	14..53	CDD:279668	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..168		4/38 (11%)
		COG5048	204..>543	CDD:227381	103/297 (35%)
		C2H2 Zn finger	220..240	CDD:275368	8/19 (42%)
		zf-H2C2_2	232..257	CDD:290200	12/24 (50%)
		C2H2 Zn finger	248..268	CDD:275368	7/19 (37%)
		zf-H2C2_2	260..283	CDD:290200	9/22 (41%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	289..313	CDD:290200	11/23 (48%)
		C2H2 Zn finger	304..324	CDD:275368	4/19 (21%)
		zf-H2C2_2	317..341	CDD:290200	2/23 (9%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		zf-H2C2_2	347..369	CDD:290200	12/21 (57%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	1/19 (5%)
		zf-H2C2_2	401..425	CDD:290200	7/23 (30%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..451	CDD:290200	7/22 (32%)
		C2H2 Zn finger	444..464	CDD:275368	10/19 (53%)
		zf-H2C2_2	456..481	CDD:290200	14/24 (58%)
		C2H2 Zn finger	472..492	CDD:275368	8/19 (42%)
		zf-H2C2_2	485..509	CDD:290200	5/11 (45%)
		C2H2 Zn finger	500..520	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910