DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zbtb49

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001381611.1	Gene:	Zbtb49 / 305428	RGDID:	1306733	Length:	758	Species:	Rattus norvegicus

Alignment Length:	299	Identity:	103/299 - (34%)
Similarity:	154/299 - (51%)	Gaps:	35/299 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 MIVIPAEGAIDEVIGEE--TLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVC 307
            ::|...|.|..|..||.  :...|..|||| |.||:.        .|..:..||.:..:.
  Rat   328 VLVRGEESAAKEDAGERAGSQTTEDKGREE-LGPESS--------REVEMPGAPASWEDP----- 378

  Fly   308 TVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRT 372
                         :|.::|   :|||.||.|||..||..|.:.|..:||..||.:|:|||:.:..
  Rat   379 -------------SQALQS---QKQYACELCGKPFKHPSNLELHKRSHTGEKPFECNICGKHFSQ 427

  Fly   373 TSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKI 437
            ..:|..|.|.|:.:|||.|:.||:.:||...::||.:.|:||:|:.||.|.:.:.:.|:|::||.
  Rat   428 AGNLQTHLRRHSGEKPYICEICGKRFAASGDVQRHIIIHSGEKPHLCDTCGRGFSNFSNLKEHKK 492

  Fly   438 SHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFK 502
            :||..|.|||:.||...:.:....||.:.|:|.:.:.|..||..|..:.:|..|||.|:||||:.
  Rat   493 THTADKVFTCDECGKSFNMQRKLVKHRVRHTGERPYSCPACGKCFGGSGDLRRHVRTHTGEKPYS 557

  Fly   503 CEVCVKAFPTKKRLASHMRVHNK---ESPVTATVAVQSI 538
            ||:|.|.|.....|..|.|:|.:   .|||......|:|
  Rat   558 CEICSKCFTRSAVLRRHKRMHGRAEARSPVVLDELSQAI 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	53/153 (35%)
		C2H2 Zn finger	307..327	CDD:275368	1/19 (5%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	54/135 (40%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	13/22 (59%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
Zbtb49	NP_001381611.1	BTB_POZ_ZBTB49	7..118	CDD:349542
		PHA03247	<121..300	CDD:223021
		zf-C2H2	388..410	CDD:395048	10/21 (48%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		COG5048	<400..578	CDD:227381	68/177 (38%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
		C2H2 Zn finger	502..522	CDD:275368	5/19 (26%)
		C2H2 Zn finger	530..550	CDD:275368	8/19 (42%)
		C2H2 Zn finger	558..578	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910