DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zbtb11

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_038944302.1	Gene:	Zbtb11 / 304010	RGDID:	1308275	Length:	1092	Species:	Rattus norvegicus

Alignment Length:	727	Identity:	130/727 - (17%)
Similarity:	234/727 - (32%)	Gaps:	293/727 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SEGSTTLASMLNYC------------TGLSFEPQDGAAMPQHICLHCLQLLEQAFNFKRMVIDSD 87
            :|.:|||:|.|.:|            |..:.||....| ||                    :.::
  Rat   347 NEATTTLSSDLGHCEIVLLVNGEVPETEQNGEPGQQPA-PQ--------------------VSAE 390

  Fly    88 ELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEE 152
              ....:..|.|         .||...:......|.:|.:..:...::.|: ..||::..:::||
  Rat   391 --AEASVSPAGC---------IPNPPTEMGAASLATESNQPELESAVVRED-GGVASVPPKISEE 443

  Fly   153 DRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNE 217
            :    .:...:|:..:..:...:|..:::....:||..|                     .:|:|
  Rat   444 N----VINTSQEDSDIGNDTSPEDTCTKDFSDHSQSSGQ---------------------PLKDE 483

  Fly   218 FETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDE---VIGEETLELEGDGRE-------- 271
             ||::...::    .|||..|.....::    .:.:::|   :...:.:|.:...|:
  Rat   484 -ETLIEATEK----TDSGQDDDTYRSRL----RQRSVNEGGYIRLHKGMEKKLQKRKAISKSAVQ 539

  Fly   272 ---EHLLPEAEDVCEDEDFLEESLDSAPPTAGE--------------------ALPYVCTVCQKA 313
               :.|:...:.:.:.:...:||.:..|...||                    |..|.|.:|:|.
  Rat   540 QVAQKLVQRGKKMKQPKRDAKESAEETPHKCGECGMVFPRRYAFIMHTLKHERARDYKCPLCKKQ 604

  Fly   314 FRQQCRLNQHMRSHV--------------------------DEKQYECEECGKRLKHLRNYKEHM 352
            |:....|..|:..|.                          .::::.|..||:.|..|.:.:.||
  Rat   605 FQYSASLRAHLIRHTRKDAPTSSSSNSTSNEASGASSEKGRTKREFICSICGRTLPKLYSLRIHM 669

  Fly   353 LTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPY 417
            |.||.||||.|.:||:.:.....|.:|:..|..:|.:.|:.|.:.:.....|:.|...||||..|
  Rat   670 LKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKY 734

  Fly   418 ACDL------------------------------------------------------------- 421
            .|.:
  Rat   735 FCSVCGKSFHRGSGLSKHLKKHQPKPEVRGYHCTQLHMDQVWQCFQLLILSASKLSRVFPGSSCK 799

  Fly   422 ----------CDKAYYDSSSLRQHKISHTGKKAFTCEI--------------------------- 449
                      |:|:::::..||||...|.|.|.|.|:.
  Rat   800 SPVFPSDWIQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCN 864

  Fly   450 -------------------------------------CGVGLSQKSGYKKHMMVHSGVKAHKCDV 477
                                                 ||...:|...|::||..|.|||..:|..
  Rat   865 ICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCDQCGRKFTQLREYRRHMNNHEGVKPFECLT 929

  Fly   478 CGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHM-------------------RVH 523
            ||.|:....:|..|||.|:||:|:.|.||.:|:...:.|..||                   :.|
  Rat   930 CGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFH 994

  Fly   524 NKESPVTATVAV 535
            |:.:.|...|::
  Rat   995 NQGTQVEHAVSI 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	13/67 (19%)
		COG5048	<297..451	CDD:227381	53/334 (16%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		COG5048	<387..523	CDD:227381	51/289 (18%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		zf-H2C2_2	403..426	CDD:290200	10/93 (11%)
		C2H2 Zn finger	419..439	CDD:275368	7/90 (8%)
		C2H2 Zn finger	447..467	CDD:275368	7/83 (8%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	7/38 (18%)
Zbtb11	XP_038944302.1	Integrase_H2C2	68..120	CDD:407771
		BTB_POZ_ZBTB11	195..312	CDD:349511
		PRK12387	<556..621	CDD:183492	14/64 (22%)
		C2H2 Zn finger	570..590	CDD:275368	2/19 (11%)
		C2H2 Zn finger	598..618	CDD:275368	6/19 (32%)
		C2H2 Zn finger	652..672	CDD:275368	8/19 (42%)
		zf-H2C2_2	664..689	CDD:404364	12/24 (50%)
		C2H2 Zn finger	680..700	CDD:275368	5/19 (26%)
		COG5048	695..>801	CDD:227381	13/105 (12%)
		C2H2 Zn finger	708..728	CDD:275368	4/19 (21%)
		C2H2 Zn finger	736..756	CDD:275368	1/19 (5%)
		C2H2 Zn finger	809..827	CDD:275368	6/17 (35%)
		zf-H2C2_2	819..843	CDD:404364	9/23 (39%)
		C2H2 Zn finger	835..855	CDD:275368	1/19 (5%)
		C2H2 Zn finger	863..885	CDD:275368	0/21 (0%)
		C2H2 Zn finger	899..919	CDD:275368	6/19 (32%)
		C2H2 Zn finger	927..947	CDD:275368	8/19 (42%)
		zf-H2C2_2	939..962	CDD:404364	11/22 (50%)
		C2H2 Zn finger	955..976	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100