DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zup1

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001008309.1	Gene:	Zup1 / 294390	RGDID:	1307672	Length:	577	Species:	Rattus norvegicus

Alignment Length:	291	Identity:	53/291 - (18%)
Similarity:	89/291 - (30%)	Gaps:	74/291 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 ESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETL 263
            |.....:.|..|..|.:..|||:...:.|...:.::..|..:                   |.|.
  Rat    43 EMCFHIETAHFEQTTPEKSFETLAAVQYENSDLGNTKLHSTV-------------------EVTS 88

  Fly   264 ELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHV 328
            .:............:|.:.:|....:|:.            |..:|.:....|:.|..|...|..
  Rat    89 GIHSACASNFPKESSESLSKDRTLKQEAF------------YTESVAESRKYQKSREKQSGLSEA 141

  Fly   329 DEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRT-HAE--KKP-- 388
            ....||                     |...|.:|..|||..|.:..:.:|.:| ||.  :.|
  Rat   142 QGSIYE---------------------TTYSPPECPFCGRIERYSQDMEIHVKTKHASLLESPLE 185

  Fly   389 ------YNCDQCGRGYAAFDHLRRHKLTHTGERPY-------AC----DLCDKAYYDSSSLRQHK 436
                  |:|..||.....:..|:.|...|..|..:       .|    :|..:...:....|:.:
  Rat   186 DCHQPLYDCPMCGLVCTNYHILQEHVDLHLEESSFQQGMDRVQCSSDRELAHQLQQEEERKRKSE 250

  Fly   437 ISHTGKKAFTCEICGVGLSQKSGYKKHMMVH 467
            .|...::.|.......||....|||:..:.|
  Rat   251 ESRQEREEFQKLQRQYGLDNSGGYKQQQLRH 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	33/175 (19%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		C2H2 Zn finger	335..355	CDD:275368	0/19 (0%)
		C2H2 Zn finger	363..383	CDD:275368	7/20 (35%)
		COG5048	<387..523	CDD:227381	20/100 (20%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	6/33 (18%)
		C2H2 Zn finger	419..439	CDD:275368	3/23 (13%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368
		zf-H2C2_2	487..510	CDD:290200
		C2H2 Zn finger	503..523	CDD:275368
Zup1	NP_001008309.1	MIU. /evidence=ECO:0000250\|UniProtKB:Q96AP4	225..247		2/21 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..262		4/30 (13%)
		zUBD/ZHA. /evidence=ECO:0000250\|UniProtKB:Q96AP4	248..273		4/24 (17%)
		Peptidase_C78	335..550	CDD:285191
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343820
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930