DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and Zfp418

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_006228239.1	Gene:	Zfp418 / 292548	RGDID:	1311663	Length:	670	Species:	Rattus norvegicus

Alignment Length:	600	Identity:	150/600 - (25%)
Similarity:	232/600 - (38%)	Gaps:	157/600 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LGSEGSTTLASMLNYCTGLSFEPQDGAAMPQHICLHCLQLLEQAFNFK----RMVIDSDELLRLG 93
            :||.||...|      ..||.||.   |..:|:...|:.:.:....|.    :::.::..||.|.
  Rat     7 VGSSGSCVRA------PALSTEPM---AAVKHLAQGCVTIEDVTVYFSQEEWKLLDEAQRLLYLD 62

  Fly    94 L-------------------DEARC----SSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEML 135
            :                   :|..|    |.....|..:|.|.|.. |:....|     :.|.:|
  Rat    63 VMLENFTLISSLVYRYEAEAEEKTCAQSLSQTEAPQVRTPKQGQLR-QKPHPSD-----ICITVL 121

  Fly   136 NEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTE--EVDQDDELSEEEHQLAQSGDQQEE---- 194
                :::.:|::             :..::.:|||  ...||.:....::.|.:..|...:
  Rat   122 ----KDILHLND-------------LPGQKPYLTEVCTKPQDHKHHRAKNWLKRDVDSLVKSCIF 169

  Fly   195 HIT-----MESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAI 254
            |:.     ...:.|..||....:..|:    |...|.:.::......|
  Rat   170 HVAGNPFICSKIGEKFPAIWNLLQPKD----IPNGEKQNKIKRGKAFH----------------- 213

  Fly   255 DEVIGEETLELEGDGREEHLLPEAEDVCE-----DEDFLEESLDSAPPT-----AGEALPYVCTV 309
            .:....|:.|.:.....:|.|.|...||.     :.:..|:.|:...|.     ..|..||.|.|
  Rat   214 RDKNNSESDEYKKSSSPQHRLHEYPGVCSAKGGFESNSCEQDLNKYSPAPFRMDQTENRPYECHV 278

  Fly   310 CQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKE------------------------ 350
            |.|.|.|:..|..|.|.|..||.|:|.||||......|..|
  Rat   279 CGKWFGQKATLRIHQRRHTGEKPYKCGECGKSFCQSSNLSEHCRVHSGERPFECLECGKAFGCHS 343

  Fly   351 ----HMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTH 411
                |..|||...|::||.|||.:|...||..|:|||..:|||.|.||.:.::....|..|:..|
  Rat   344 SLLRHQRTHTGEWPYECSDCGRLFRQIVSLITHQRTHTTEKPYECGQCEKSFSHKATLTVHQRVH 408

  Fly   412 TGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHM------------ 464
            |||:||.|:.|.|::..|::|.:|...|||:|.:.|..||:...|::...||.
  Rat   409 TGEKPYHCEACGKSFSQSANLIKHSKIHTGEKPYECGECGLCFRQRATLMKHQRTHTSERPYECR 473

  Fly   465 ----------------MVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTK 513
                            .:|:..:.::|:.||.::|..:.|..|.|:|:||.|:|||.|.|||..|
  Rat   474 ECGKFFKQYFYLIEHRRIHTTTEFYECEQCGKSYTQKATLIRHQRVHTGESPYKCEECGKAFEYK 538

  Fly   514 KRLASHMRVHNKESP 528
            .||..|.|.|..|.|
  Rat   539 SRLKRHQRTHTGERP 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	14/61 (23%)
		COG5048	<297..451	CDD:227381	66/186 (35%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	8/47 (17%)
		C2H2 Zn finger	363..383	CDD:275368	10/19 (53%)
		COG5048	<387..523	CDD:227381	54/163 (33%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	6/47 (13%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	11/19 (58%)
Zfp418	XP_006228239.1	KRAB	35..>76	CDD:214630	4/40 (10%)
		KRAB	35..74	CDD:279668	4/38 (11%)
		COG5048	<190..396	CDD:227381	60/226 (27%)
		C2H2 Zn finger	276..296	CDD:275368	9/19 (47%)
		zf-H2C2_2	289..311	CDD:290200	12/21 (57%)
		COG5048	300..657	CDD:227381	82/253 (32%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		zf-H2C2_2	316..339	CDD:290200	2/22 (9%)
		C2H2 Zn finger	332..352	CDD:275368	1/19 (5%)
		zf-H2C2_2	344..369	CDD:290200	10/24 (42%)
		C2H2 Zn finger	360..380	CDD:275368	10/19 (53%)
		zf-H2C2_2	372..397	CDD:290200	12/24 (50%)
		C2H2 Zn finger	388..408	CDD:275368	5/19 (26%)
		zf-H2C2_2	401..425	CDD:290200	11/23 (48%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		C2H2 Zn finger	444..464	CDD:275368	6/19 (32%)
		zf-H2C2_2	457..481	CDD:290200	2/23 (9%)
		C2H2 Zn finger	472..492	CDD:275368	0/19 (0%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		zf-H2C2_2	513..537	CDD:290200	14/23 (61%)
		C2H2 Zn finger	528..548	CDD:275368	11/19 (58%)
		zf-H2C2_2	541..563	CDD:290200	5/12 (42%)
		C2H2 Zn finger	556..576	CDD:275368
		zf-H2C2_2	568..593	CDD:290200
		C2H2 Zn finger	584..604	CDD:275368
		zf-H2C2_2	596..621	CDD:290200
		C2H2 Zn finger	612..632	CDD:275368
		zf-H2C2_2	624..649	CDD:290200
		C2H2 Zn finger	640..660	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100